Department of Respiratory Diseases, PLA Rocket Force Characteristic Medical Center, Beijing, China.
Eur Rev Med Pharmacol Sci. 2022 Jun;26(11):4001-4015. doi: 10.26355/eurrev_202206_28971.
The objective of this study was to investigate the effects of long-duration space flight on the biological characteristics of Acinetobacter schindleri (A. schindleri).
In this study, an A. schindleri strain was collected from condensate water of the Shenzhou-10 spacecraft and then was sent into space again to the Tiangong-2 space lab for a long-duration spaceflight (64 days). Later, the impacts of the long-duration spaceflight on phenotype, genome and transcriptome of A. schindleri were analyzed.
It was found that the long-duration spaceflight markedly decreased the growth rate and biofilm formation ability of A. schindleri. Furthermore, comparative genomic and transcriptomic analyses revealed that the decreased growth rate might be associated with differentially expressed genes (DEGs) involved in transmembrane transport, energy production and conversion, and biofilm was reduced due to downregulation of the pil and algR genes.
The findings are of major importance for predicting bacterial pathogenesis mechanisms and possible spacecraft contamination during long-duration spaceflights in the future.
本研究旨在探讨长时间空间飞行对不动杆菌（A. schindleri）生物学特性的影响。
本研究从神舟十号飞船冷凝水中采集了一株不动杆菌菌株，然后再次送入天宫二号空间实验室进行长时间空间飞行（64 天）。随后，分析了长时间空间飞行对不动杆菌表型、基因组和转录组的影响。
研究发现，长时间空间飞行显著降低了不动杆菌的生长速率和生物膜形成能力。此外，比较基因组和转录组分析表明，生长速率的降低可能与参与跨膜运输、能量产生和转化的差异表达基因（DEGs）有关，生物膜的减少是由于 pil 和 algR 基因的下调。
这些发现对于预测未来长时间空间飞行中细菌发病机制和可能的航天器污染具有重要意义。
