Department of Urology, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA.
Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Neurourol Urodyn. 2022 Aug;41(6):1505-1510. doi: 10.1002/nau.24998. Epub 2022 Jun 22.
This study aimed to determine the impact of pregnancy and pregnancy-associated characteristics on nocturia.
Using the National Health and Nutrition Examination Survey (NHANES) database from 2005/06 to 2017/18, we analyzed women who completed the "Reproductive Health" and "Kidney Conditions-Urology" questionnaires by sorting them into three groups: nulligravida, previously pregnant (nonpregnant with prior pregnancies), and currently pregnant. After excluding patients with pre-existing conditions impacting nocturia or with incomplete data, we weighed and matched the groups for age, race, BMI, and number of pregnancies. The relationships of nocturia to pregnancy in all groups and pregnancy-associated characteristics (gestational diabetes mellitus [GDM], history of multiple pregnancies, and trimesters of pregnancy) in currently pregnant women were assessed.
Of 8330 women that indicated pregnancy status, 1544 women (age range: 20-44 years; 523 nulligravida, 498 previously pregnant, 523 currently pregnant women) were included in analysis. Currently, pregnant women had a higher prevalence of nocturia than previously pregnant and nulligravida women (56.4% vs. 22.5% vs. 16.1%, p < 0.001) and had the highest odds of nocturia (OR: 6.82, p < 0.001). GDM or history of multiple pregnancies showed no associations in currently pregnant women. Increasing trimesters were associated with nocturia, with the third trimester showing the highest odds (OR: 10.35, p < 0.001) and a greater average of nighttime voids than the first and second trimesters (2.40 ± 1.42 vs. 1.56 ± 1.31 and 1.88 ± 1.32, p < 0.001).
The association noted between pregnancy and nocturia, which strengthened with increasing trimesters, demonstrates that nocturia can significantly impact quality of life and therefore must be addressed during pregnancy.
本研究旨在探讨妊娠及其相关特征对夜尿症的影响。
利用 2005/06 年至 2017/18 年的国家健康和营养调查（NHANES）数据库，我们通过对完成“生殖健康”和“肾脏状况-泌尿科”问卷的女性进行分类，将其分为三组：未生育者、曾妊娠者（无妊娠但有既往妊娠）和现妊娠者。排除有影响夜尿症的既往疾病或数据不完整的患者后，我们对各组进行体重和匹配，以调整年龄、种族、BMI 和妊娠次数的影响。评估所有组中夜尿症与妊娠的关系，以及现妊娠女性的妊娠相关特征（妊娠期糖尿病[GDM]、多胎妊娠史和妊娠周期）。
在 8330 名报告妊娠状况的女性中，有 1544 名女性（年龄范围：20-44 岁；523 名未生育者、498 名曾妊娠者、523 名现妊娠者）纳入分析。现妊娠女性的夜尿症患病率高于曾妊娠者和未生育者（56.4%比 22.5%比 16.1%，p<0.001），且夜尿症的可能性最高（OR：6.82，p<0.001）。现妊娠女性的 GDM 或多胎妊娠史与夜尿症无关。妊娠周期的增加与夜尿症有关，其中第三个周期的可能性最高（OR：10.35，p<0.001），且夜间排尿次数多于第一和第二周期（2.40±1.42 比 1.56±1.31 和 1.88±1.32，p<0.001）。
妊娠与夜尿症之间的关联随着妊娠周期的增加而增强，表明夜尿症会显著影响生活质量，因此必须在妊娠期间予以重视。
