Department of Translational Research NTMC, University of Pisa, Italy.
Department of Clinical and Experimental Medicine, University of Pisa, Italy.
Clin Exp Immunol. 2022 Sep 29;209(3):305-310. doi: 10.1093/cei/uxac060.
Glutathione S-transferase omega-1 (GSTO1-1) is a cytosolic enzyme involved in the modulation of critical inflammatory pathways as well as in cancer progression. Auto-antibodies against GSTO1-1 were detected in the serum of patients with esophageal squamous cell carcinoma and were proposed as potential biomarkers in the early detection of the disease. Our findings show that anti-GSTO1-1 antibodies can be found in a variety of inflammatory diseases, including autoimmune rheumatoid arthritis, infectious SARS-CoV-2, and trichinellosis. Our findings strongly suggest that anti-GSTO1-1 antibodies may be a marker of tissue damage/inflammation rather than a specific tumor-associated biomarker.
谷胱甘肽 S-转移酶 ω-1（GSTO1-1）是一种细胞溶质酶，参与调节关键的炎症途径以及癌症的进展。在食管鳞状细胞癌患者的血清中检测到针对 GSTO1-1 的自身抗体，并被提议作为该疾病早期检测的潜在生物标志物。我们的研究结果表明，针对 GSTO1-1 的抗体可以在多种炎症性疾病中发现，包括自身免疫性类风湿关节炎、传染性 SARS-CoV-2 和旋毛虫病。我们的研究结果强烈表明，针对 GSTO1-1 的抗体可能是组织损伤/炎症的标志物，而不是特定的肿瘤相关生物标志物。
