Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung, 80424, Taiwan.
Department of Dentistry, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, 81342, Taiwan.
Sci Rep. 2022 Jun 22;12(1):10513. doi: 10.1038/s41598-022-14052-w.
Oral squamous cell carcinoma (OSCC) is a common malignant tumor worldwide that is characterized by abnormal lesions or malignant hyperplasia of soft and hard tissues in the oral cavity. Previous research has found that HDAC6 may be a potential therapeutic target for cancer patients and has the ability to regulate immune cells. However, the mechanism of HDAC6 in OSCC pathogenesis is unclear. We collected clinical samples and analyzed the level of HDAC6 in OSCC patients. The results showed that in the high HDAC6 expression group, HDAC6 expression was positively correlated with the grade of OSCC (R = 0.182, P = 0.036) and that this group had a 3.248-fold increase in the mortality risk compared with the low HDAC6 expression group (P = 0.003). Survival analysis also identified a correlation between the expression of HDAC6 and overall survival in OSCC patients, and it was found that the expression of HDAC6 was inversely correlated with survival (P ≤ 0.001). In addition, we found that HDAC6 induced IL-13 expression through AP-1, resulting in M2 polarization of macrophages. Together, these results demonstrate that the level of HDAC6 may be a useful prognostic biomarker and offer a novel immune cell-related therapeutic strategy of targeting IL-13 in OSCC.
口腔鳞状细胞癌（OSCC）是一种常见的恶性肿瘤，其特征是口腔软硬组织的异常病变或恶性增生。先前的研究发现，HDAC6 可能是癌症患者的一个潜在治疗靶点，并且具有调节免疫细胞的能力。然而，HDAC6 在 OSCC 发病机制中的作用机制尚不清楚。我们收集了临床样本并分析了 OSCC 患者中 HDAC6 的水平。结果表明，在 HDAC6 高表达组中，HDAC6 的表达与 OSCC 的分级呈正相关（R = 0.182，P = 0.036），并且与 HDAC6 低表达组相比，该组的死亡率增加了 3.248 倍（P = 0.003）。生存分析还确定了 HDAC6 的表达与 OSCC 患者总生存率之间的相关性，并且发现 HDAC6 的表达与生存率呈负相关（P ≤ 0.001）。此外，我们发现 HDAC6 通过 AP-1 诱导 IL-13 的表达，导致巨噬细胞的 M2 极化。综上所述，这些结果表明，HDAC6 的水平可能是一个有用的预后生物标志物，并提供了一种针对 OSCC 中 IL-13 的新型免疫细胞相关治疗策略。
