Dong Xiaodan, Dong Chunling, Li Bo
Department of Oral Anatomy and Physiology, Jilin Provincial Key Laboratory of Oral Biomedical Engineering, Hospital of Stomatology, Jilin University, Changchun, China.
School of Public Health, Jilin University, Changchun, China.
Front Immunol. 2025 Jan 14;15:1517886. doi: 10.3389/fimmu.2024.1517886. eCollection 2024.
Macrophages are crucial immune cells within the tumor microenvironment (TME), involved in regulating tumor proliferation, invasion, metastasis, ECM remodeling, angiogenesis, and immunosuppression. Although more and more experimental evidence and clinical data indicate that macrophages are involved in the onset and progression of oral squamous cell carcinoma (OSCC), the exact pathogenesis of OSCC associated with macrophages has not been fully elucidated. Enhanced knowledge of the molecular mechanisms involving macrophages in OSCC will aid in the creation of treatments targeted specifically at macrophages. This review outlines the pro-tumoral and anti-tumoral effects of macrophages in OSCC, emphasizing the interaction between OSCC cells and macrophages. It can provide theoretical basis for the establishment of complex regulatory network centered on macrophages and explore novel therapeutic strategies for OSCC.
巨噬细胞是肿瘤微环境（TME）中的关键免疫细胞，参与调节肿瘤增殖、侵袭、转移、细胞外基质重塑、血管生成和免疫抑制。尽管越来越多的实验证据和临床数据表明巨噬细胞参与口腔鳞状细胞癌（OSCC）的发生和发展，但与巨噬细胞相关的OSCC的确切发病机制尚未完全阐明。深入了解巨噬细胞在OSCC中的分子机制将有助于开发专门针对巨噬细胞的治疗方法。本综述概述了巨噬细胞在OSCC中的促肿瘤和抗肿瘤作用，强调了OSCC细胞与巨噬细胞之间的相互作用。它可为建立以巨噬细胞为中心的复杂调控网络提供理论依据，并探索OSCC的新型治疗策略。
