Keck School of Medicine, University of Southern California, 1975 Zonal Ave., Los Angeles, CA, 90033, USA.
Department of Obstetrics and Gynecology, University of Nevada, 1701 W Charleston Blvd., Ste. 290, Las Vegas, NV, 89102, USA.
Langenbecks Arch Surg. 2022 Dec;407(8):3803-3810. doi: 10.1007/s00423-022-02584-8. Epub 2022 Jun 22.
To investigate the effect of postoperative prune consumption on time to first bowel movement after benign gynecologic surgery.
In this randomized, open label, controlled trial, 77 adult women who had benign gynecologic surgery that required at least one night in the hospital were enrolled from July 2018 to April 2019. Participants were randomized in a 1:1 ratio to one of two groups using a randomization assignment: 4 oz prunes daily plus docusate sodium 100 g twice daily versus docusate alone. The study's primary objective was time to first bowel movement (BM). Secondary outcomes were pain associated with first BM, stool consistency using Bristol stool scale, and patient satisfaction with bowel regimen and surgery experience.
Postoperative survey data was available for 68.4% of participants (n = 52). There was no difference in time to first BM between the two groups (p = 0.29); however, consumption of > 12 prunes was associated with an increased likelihood of having a BM in the study period. Among women who consumed at least 12 prunes, hospital discharge was earlier, and there was a not statistically significant greater satisfaction with postoperative bowel regimen.
The addition of prunes to postoperative bowel regimen of docusate sodium may be a beneficial adjunct to postoperative bowel regimen.
The Institutional Review Board at the University of Southern California approved the study, and the study was registered at clinicaltrials.gov (ID: NCT03523715).
研究良性妇科手术后食用西梅对首次排便时间的影响。
本随机、开放标签、对照试验纳入了 2018 年 7 月至 2019 年 4 月间进行需至少住院一晚的良性妇科手术的 77 名成年女性。参与者按照 1:1 的比例随机分为两组，分别接受每日 4 盎司西梅加每日两次 100 克多库酯钠或单独使用多库酯钠治疗。该研究的主要目标是首次排便时间（BM）。次要结局包括首次 BM 时的疼痛程度、使用布里斯托粪便量表评估的粪便稠度，以及患者对肠道管理方案和手术体验的满意度。
68.4%的参与者（n=52）术后进行了调查。两组首次 BM 时间无差异（p=0.29）；然而，食用>12 个西梅与研究期间更有可能排便有关。在食用至少 12 个西梅的女性中，出院更早，且对术后肠道管理方案的满意度更高，但差异无统计学意义。
在多库酯钠术后肠道管理方案中添加西梅可能是一种有益的辅助治疗。
南加州大学的机构审查委员会批准了该研究，并在 clinicaltrials.gov 上注册（ID：NCT03523715）。
