Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Neuropsychopharmacol Rep. 2022 Sep;42(3):281-287. doi: 10.1002/npr2.12261. Epub 2022 Jun 22.
Cognitive impairment is a prominent cause of disability in schizophrenia. Although antipsychotic drugs can rescue the psychotic symptoms, the cognitive impairments persist, with no treatment available. Alterations of BDNF, VEGF, TNF-α, and S100B have been linked to cognitive impairment in several neurological disorders. However, it remains unclear whether their levels are correlated with the cognitive functions of schizophrenia patients. Forty-one chronic, medicated schizophrenia patients were included in this study. Enzyme-linked, immunosorbent assays were used to measure the serum concentrations of BDNF, VEGF, TNF-α, and S100B. Associations between serum protein levels and various domains of the cognitive functions of the schizophrenia patients were observed. We found significant, positive correlations between serum BDNF and the processing speed and attention levels of the patients. Serum VEGF was also positively correlated with their memory and learning functions. In contrast, serum S100B and TNF-α were negatively correlated with the processing speed and attention of the schizophrenia patients. The findings warrant further investigation of these molecules as potential prognostic markers or treatment targets for cognitive impairment in schizophrenia patients.
认知障碍是精神分裂症致残的主要原因。虽然抗精神病药物可以挽救精神病症状，但认知障碍仍然存在，而且没有有效的治疗方法。BDNF、VEGF、TNF-α 和 S100B 的改变与几种神经紊乱中的认知障碍有关。然而，它们的水平是否与精神分裂症患者的认知功能相关仍然不清楚。本研究纳入了 41 名慢性、用药的精神分裂症患者。采用酶联免疫吸附试验检测血清 BDNF、VEGF、TNF-α 和 S100B 浓度。观察了血清蛋白水平与精神分裂症患者认知功能各领域之间的关系。我们发现血清 BDNF 与患者的处理速度和注意力呈显著正相关。血清 VEGF 也与他们的记忆和学习功能呈正相关。相反，血清 S100B 和 TNF-α 与精神分裂症患者的处理速度和注意力呈负相关。这些发现表明这些分子作为精神分裂症患者认知障碍的潜在预后标志物或治疗靶点值得进一步研究。
