Su Qi, Liu Changcun, Zhu Jingyi, Ding Mengbin, Zhang Zhen, Li Jingchao, Zhang Qin
Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Bioeng Biotechnol. 2022 Jun 6;10:919235. doi: 10.3389/fbioe.2022.919235. eCollection 2022.
Hepatic carcinoma is one of the most common cancers worldwide, while its treatment remains a great challenge. Traditional therapeutic methods often have disadvantages such as limited therapeutic efficacy and potential side effects. In this study, we report the construction of bovine serum albumin (BSA)-stabilized manganese oxide (MnO)/semiconducting polymer (SP) nanocomposites to combine photothermal therapy (PTT) and chemodynamic therapy (CDT) for treatment of hepatic carcinoma in living mouse models. Such nanocomposites are composed of BSA, SP, and MnO as the stabilizer, PTT, and CDT agent, respectively. SP produced local heat under near-infrared (NIR) laser irradiation for PTT, and MnO nanoparticles mediated CDT in the tumor microenvironment, leading to apoptosis of cancer cells. Such nanocomposite-mediated combinational therapy showed a much higher efficacy in inhibiting growth of subcutaneous HepG2 tumors in nude mice than sole treatment. This study thus provides a multifunctional nanoplatform for safe and effective treatment of hepatic carcinoma.
肝癌是全球最常见的癌症之一，而其治疗仍然是一个巨大的挑战。传统治疗方法往往存在治疗效果有限和潜在副作用等缺点。在本研究中，我们报道了构建牛血清白蛋白（BSA）稳定的氧化锰（MnO）/半导体聚合物（SP）纳米复合材料，以结合光热疗法（PTT）和化学动力学疗法（CDT）用于活体小鼠模型中的肝癌治疗。这种纳米复合材料分别由BSA、SP和MnO组成，作为稳定剂、PTT和CDT剂。SP在近红外（NIR）激光照射下产生局部热量用于PTT，而MnO纳米颗粒在肿瘤微环境中介导CDT，导致癌细胞凋亡。这种纳米复合材料介导的联合疗法在抑制裸鼠皮下HepG2肿瘤生长方面比单一治疗显示出更高的疗效。因此，本研究为安全有效地治疗肝癌提供了一种多功能纳米平台。
