Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University, Detroit, MI, United States.
Front Endocrinol (Lausanne). 2022 Jun 6;13:915031. doi: 10.3389/fendo.2022.915031. eCollection 2022.
Retinopathy is one of the most devastating complications of diabetes, which a patient fears the most. Hyperglycemic environment results in many structural, functional, molecular and biochemical abnormalities in the retina, and overproduction of mitochondrial superoxide, induced by hyperglycemic milieu, is considered to play a central role in the development of diabetic retinopathy. Expression of many genes associated with maintaining mitochondrial homeostasis is also altered. Recent research has shown that several long noncoding RNAs, RNAs with more than 200 nucleotides but without any reading frames, are aberrantly expressed in diabetes, and altered expression of these long noncoding RNAs is now being implicated in the development of diabetes and its complications including retinopathy. This review focuses the role of long noncoding RNAs in the development of diabetic retinopathy, with a special emphasis on the maintenance of mitochondrial homeostasis.
糖尿病性视网膜病变是糖尿病最严重的并发症之一，也是患者最担心的并发症之一。高血糖环境会导致视网膜发生许多结构、功能、分子和生化异常，而高血糖环境诱导的线粒体超氧化物的过度产生被认为在糖尿病性视网膜病变的发生发展中起核心作用。与维持线粒体动态平衡相关的许多基因的表达也发生了改变。最近的研究表明，几种长链非编码 RNA（长度超过 200 个核苷酸但没有任何阅读框的 RNA）在糖尿病中异常表达，这些长链非编码 RNA 的表达改变与糖尿病及其并发症（包括视网膜病变）的发生发展有关。本文重点探讨了长链非编码 RNA 在糖尿病性视网膜病变发展中的作用，特别强调了维持线粒体动态平衡的作用。
