改良格拉斯哥预后评分可预测 CEA 和 CA19-9 正常的胃癌患者的生存情况。
The Modified Glasgow Prognostic Score Predicts Survival in Gastric Cancer Patients with Normal CEA and CA19-9.
机构信息
Department of Gastrointestinal Surgery, Shanghai East Hospital, Tongji University, Shanghai, China.
Center of Digestive Endoscopy, Shanghai East Hospital, Tongji University, Shanghai, China.
出版信息
Can J Gastroenterol Hepatol. 2022 Jun 13;2022:3953004. doi: 10.1155/2022/3953004. eCollection 2022.
BACKGROUND
Traditionally, serum CEA and CA19-9 levels are good prognostic factors for gastric cancer. Many gastric cancer patients do not have elevated CEA or CA19-9 levels even at a very advanced stage. This study investigates the significance of the modified Glasgow prognostic score (mGPS) for the survival of gastric cancer patients with normal CEA and CA19-9.
METHODS
We retrospectively examined 488 curatively resected gastric cancer patients with normal preoperative serum levels of CEA and CA19-9 to evaluate the prognostic ability of mGPS for overall survival. The prognostic significance was analyzed by univariate and multivariate analyses.
RESULTS
Age, hemoglobin, white cell count, and neutrophils were each significantly correlated with the mGPS. Multivariate analyses showed that tumor location (HR, 0.803; 95% CI, 0.667-0.966; =0.020), TNM stage (HR, 2.714; 95% CI, 2.250-3.275; < 0.001), and mGPS (HR, 1.042; 95% CI, 1.105-1.772; =0.023) were significantly associated with overall survival. Significant correlations were found between overall survival and mGPS. The Kaplan-Meier analysis demonstrated significant differences among patients with mGPS of 0, 1, and 2 ( < 0.001), with the mortality rate being higher for patients with a higher mGPS.
CONCLUSION
The mGPS can predict survival in gastric cancer patients with normal CEA and CA19-9.
背景
传统上，血清 CEA 和 CA19-9 水平是胃癌的良好预后因素。许多胃癌患者即使在晚期也没有升高的 CEA 或 CA19-9 水平。本研究探讨了改良格拉斯哥预后评分（mGPS）对 CEA 和 CA19-9 正常的胃癌患者生存的意义。
方法
我们回顾性检查了 488 例经根治性切除的 CEA 和 CA19-9 术前血清水平正常的胃癌患者，以评估 mGPS 对总生存的预后能力。通过单因素和多因素分析进行预后意义分析。
结果
年龄、血红蛋白、白细胞计数和中性粒细胞与 mGPS 均有显著相关性。多因素分析显示，肿瘤位置（HR，0.803；95%CI，0.667-0.966；=0.020）、TNM 分期（HR，2.714；95%CI，2.250-3.275；<0.001）和 mGPS（HR，1.042；95%CI，1.105-1.772；=0.023）与总生存显著相关。总生存与 mGPS 之间存在显著相关性。Kaplan-Meier 分析显示 mGPS 为 0、1 和 2 的患者之间存在显著差异（<0.001），mGPS 较高的患者死亡率更高。
结论
mGPS 可预测 CEA 和 CA19-9 正常的胃癌患者的生存。
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