Zhu Jie-Wen, Gong Ling-Zhen, Wang Qian-Wen
Department of Clinical Laboratory, Huangshi Central Hospital (Affiliated Hospital of Hubei Polytechnic University), Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi Tumor Molecular Diagnosis and Treatment Key Laboratory, Huangshi 435000, Hubei Province, China.
World J Gastrointest Surg. 2024 Sep 27;16(9):2808-2814. doi: 10.4240/wjgs.v16.i9.2808.
Gastric cancer is a kind of malignant tumor which is prevalent all over the world. Although some progress has been made in the treatment of gastric cancer, its prognosis is still not optimistic, so it is of great significance to find reliable prognostic indicators to guide the treatment and management of patients with gastric cancer.
To explore the relationship between serum levels of five biomarkers [carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, CA72-4, CA24-2, and ferritin] and prognosis in patients with gastric cancer.
This study included 200 patients with gastric adenocarcinoma, and conducted an in-depth analysis of their baseline characteristics, relationship between tumor markers and staging, and prognosis. The study found that CA19-9 has a significant correlation with tumor stage, the average levels of CA24-2, CEA, CA72-4 and ferritin were slightly increased disregarding the stage of tumor. Survival analysis showed that increases in CEA, CA19-9, CA24-2, and ferritin were all associated with shortened overall survival of patients. Further multivariate analysis revealed that elevated serum CA72-4 levels were an independent adverse prognostic factor.
This study reveals that there is a significant correlation between the expression levels of serum tumor markers CEA, CA19-9, CA72-4, CA24-2 and ferritin in patients with gastric cancer and prognosis, and can be used as important indicators for prognostic evaluation of gastric cancer. In particular, markers that appear abnormally elevated initially may help identify gastric cancer patients with poor prognosis.
Serum CEA and CA19-9 play an important role in the prognosis assessment of gastric cancer, and are effective tools to guide clinical practice and optimize individualized treatment strategies for gastric cancer patients.
胃癌是一种在全球范围内普遍存在的恶性肿瘤。尽管在胃癌治疗方面已取得一些进展，但其预后仍然不容乐观，因此寻找可靠的预后指标以指导胃癌患者的治疗和管理具有重要意义。
探讨血清中五种生物标志物[癌胚抗原（CEA）、糖类抗原（CA）19-9、CA72-4、CA24-2和铁蛋白]水平与胃癌患者预后的关系。
本研究纳入200例胃腺癌患者，深入分析其基线特征、肿瘤标志物与分期的关系以及预后情况。研究发现CA19-9与肿瘤分期显著相关，CA24-2、CEA、CA72-4和铁蛋白的平均水平无论肿瘤分期如何均略有升高。生存分析表明，CEA、CA19-9、CA24-2和铁蛋白的升高均与患者总生存期缩短相关。进一步的多因素分析显示，血清CA72-4水平升高是独立的不良预后因素。
本研究表明，胃癌患者血清肿瘤标志物CEA、CA19-9、CA72-4、CA24-2和铁蛋白的表达水平与预后显著相关，并可作为胃癌预后评估的重要指标。特别是，最初出现异常升高的标志物可能有助于识别预后不良的胃癌患者。
血清CEA和CA19-9在胃癌预后评估中起重要作用，是指导临床实践和优化胃癌患者个体化治疗策略的有效工具。
