ElhamKia Maryam, Setayesh Leila, Yarizadeh Habib, Pooyan Sara, Veisy Zahra, Aghamohammadi Vajihe, Casazza Krista, Mirzaei Khadijeh
Nutrition and Diet Therapy, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Nutrition and Diet Therapy, Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Nutr Metab Insights. 2022 Jun 16;15:11786388221105984. doi: 10.1177/11786388221105984. eCollection 2022.
The current prevalence of the metabolically healthy obesity is about 3%. Genetic and nutrition are influencers of such phenotypes. The main goal of this study was to assess the interaction between Dietary Total Antioxidant Capacity (DTAC) and the genotypes of MC4R and Insulin resistance in metabolically healthy/unhealthy overweight and obese women in Iran.
This cross-sectional study was conducted on 237 overweight-obese women with a mean age of 36. The value of Dietary total antioxidant capacity (DTAC) was calculated using the following indices: Total reactive antioxidant potential (TRAP), Trolox equivalent antioxidant capacity (TEAC), and ferric reducing ability of plasma (FRAP). The Metabolic health status was evaluated using the Karelis criteria. Melanocortin 4 receptor single nucleotide polymorphisms were determined by the restriction fragment length polymorphism (PCR-RFLP) method. Also, insulin resistance was evaluated through homeostasis model assessment (HOMA).
Our data noted that 72.96% of participants presented Unhealthy Metabolically and 26.94% Healthy Metabolically including 33.5% of the total had T/T genotype, 23.8% had the C/T genotype, and 42.5% had the C/C genotype ( = .05). A linear regression model test showed that the probability of metabolically healthy obesity was significantly higher in patients with the T/C genotype. The test value was statistically significant (95% CI: 0.000-0.001; = .056, β = 0). No statistically significant relation was observed between study parameters and DTAC values. HOMA-Index was higher in all unhealthy subjects significantly.
The findings indicated that there are significant associations between genotypes of rs1333048 SNP and DTAC. The C/C genotype subjects with higher DTAC had a better lipid profile and were metabolically healthier.
目前代谢健康型肥胖的患病率约为3%。遗传和营养是此类表型的影响因素。本研究的主要目的是评估伊朗代谢健康/不健康的超重和肥胖女性的膳食总抗氧化能力（DTAC）与MC4R基因和胰岛素抵抗之间的相互作用。
本横断面研究对237名平均年龄为36岁的超重肥胖女性进行。膳食总抗氧化能力（DTAC）的值通过以下指标计算：总反应性抗氧化潜力（TRAP）、Trolox等效抗氧化能力（TEAC）和血浆铁还原能力（FRAP）。使用卡雷利斯标准评估代谢健康状况。通过限制性片段长度多态性（PCR-RFLP）方法测定黑皮质素4受体单核苷酸多态性。此外，通过稳态模型评估（HOMA）评估胰岛素抵抗。
我们的数据显示，72.96%的参与者代谢不健康，26.94%代谢健康，其中33.5%的总人数具有T/T基因型，23.8%具有C/T基因型，42.5%具有C/C基因型（P = 0.05）。线性回归模型测试表明，T/C基因型患者代谢健康型肥胖的概率显著更高。测试值具有统计学意义（95%CI：0.000 - 0.001；P = 0.056，β = 0）。研究参数与DTAC值之间未观察到统计学显著关系。所有不健康受试者的HOMA指数均显著更高。
研究结果表明，rs1333048 SNP的基因型与DTAC之间存在显著关联。DTAC较高的C/C基因型受试者具有更好的血脂谱，代谢更健康。
