Behzadi Amirhossein, Imani Sadegh, Deravi Niloofar, Mohammad Taheri Zahra, Mohammadian Fatemeh, Moraveji Zahra, Shavysi Sepideh, Mostafaloo Motahareh, Soleimani Hadidi Fateme, Nanbakhsh Sepehr, Olangian-Tehrani Sepehr, Marabi Mohammad Hesam, Behshood Parisa, Poudineh Mohadeseh, Kheirandish Ali, Keylani Kimia, Behfarnia Pooya
School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Avicennet, Tehran, Iran.
Nutr Metab Insights. 2023 Jan 12;16:11786388221146683. doi: 10.1177/11786388221146683. eCollection 2023.
The use of synthetic drugs has increased in recent years; however, herbal medicine is yet more trusted among a huge population worldwide; This could be due to minimal side effects, affordable prices, and traditional beliefs. Lemongrass () has been widely used for reducing stress and anxiety, increasing appetite and sleep, reducing pain, healing wounds, and treating poisonous insect bites and bee stings for a long time. Today, research has shown that this plant can also fight viruses including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Herpes Simplex Virus (HSV), and Human Immunodeficiency Virus (HIV) through various mechanisms such as inhibiting HSV-1 from binding to host cell, inhibiting HSV-1 replication during the post-adsorption or inhibiting main protease and spike protein of SARS-CoV-2, furthermore, be effective in treating related diseases. This Review investigated the antiviral properties of and its effect on viral diseases. More in vitro and in vivo studies are needed to determine underlying mechanism, and more randomized controlled trials should be done to identify its effect in humans. Also, due to the usefulness and lack of side effects, it can be used more as a complementary medicine.
近年来，合成药物的使用有所增加；然而，草药在全球大量人群中更受信任；这可能是由于副作用小、价格实惠以及传统观念。长期以来，柠檬草已被广泛用于减轻压力和焦虑、增加食欲和改善睡眠、减轻疼痛、愈合伤口以及治疗毒虫叮咬和蜜蜂蜇伤。如今，研究表明这种植物还可以通过多种机制对抗病毒，包括严重急性呼吸综合征冠状病毒2（SARS-CoV-2）、单纯疱疹病毒（HSV）和人类免疫缺陷病毒（HIV），例如抑制HSV-1与宿主细胞结合、在吸附后抑制HSV-1复制或抑制SARS-CoV-2的主要蛋白酶和刺突蛋白，此外，对治疗相关疾病有效。本综述研究了柠檬草的抗病毒特性及其对病毒性疾病的影响。需要更多的体外和体内研究来确定其潜在机制，并且应该进行更多的随机对照试验来确定其对人类的影响。此外，由于其有效性和无副作用，它可以更多地用作补充药物。
