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鼓室内注射类固醇治疗梅尼埃病后的生活质量。

Quality of life after intratympanic steroid injection for Ménière's disease.

作者信息

Schenck Annejet A, Bommeljé Claire C, van Benthem Peter Paul G, Blom Henk M

机构信息

Department of Otorhinolaryngology HagaHospital The Hague The Netherlands.

Department of Otorhinolargyngology Leiden University Medical Centre Leiden The Netherlands.

出版信息

Laryngoscope Investig Otolaryngol. 2022 May 17;7(3):825-831. doi: 10.1002/lio2.798. eCollection 2022 Jun.

Abstract

OBJECTIVE

This study explores how treatment with intratympanic steroid injection affects quality of life, as well as several subjective complaints in patients with Ménière's disease.

METHODS

Patients filled in the Ménière's Disease Outcome Questionnaire (MDOQ) and answered questions about subjective complaints. Scores before and after treatment were compared using paired tests.

RESULTS

Forty-nine patients treated with intratympanic steroid injection were included. Quality of life was improved in 36 (73%) patients, the same in 9 (18%) patients, and lower in 4 (8%) patients. Overall, the mean change in MDOQ was +20.6 points (95% confidence interval +14.5 to +26.7 points,  < 0.001). The improvement was seen in the emotional, physical, and mental domain. Most patients experienced less vertigo and instability but did not notice change in subjective hearing, tinnitus, or aural fullness after treatment.

CONCLUSION

Treatment with intratympanic steroid injection leads to an improvement in quality of life in most patients. Moreover, the procedure is only minimally invasive. Based on the findings in this study, treatment with ITS should be discussed with every patient suffering from vertigo attacks due to active Ménière's disease.

LEVEL OF EVIDENCE

Level 4.

摘要

目的

本研究探讨鼓室内注射类固醇治疗对梅尼埃病患者生活质量以及若干主观症状的影响。

方法

患者填写梅尼埃病结局问卷(MDOQ)并回答有关主观症状的问题。使用配对检验比较治疗前后的得分。

结果

纳入49例接受鼓室内注射类固醇治疗的患者。36例(73%)患者生活质量得到改善,9例(18%)患者生活质量不变,4例(8%)患者生活质量下降。总体而言,MDOQ的平均变化为+20.6分(95%置信区间为+14.5至+26.7分,<0.001)。在情感、身体和心理领域均有改善。大多数患者眩晕和不稳症状减轻,但治疗后主观听力、耳鸣或耳胀满感无变化。

结论

鼓室内注射类固醇治疗可使大多数患者生活质量得到改善。此外,该治疗方法微创性极小。基于本研究结果,对于每一位因活动性梅尼埃病而眩晕发作的患者,均应讨论鼓室内注射类固醇治疗。

证据水平

4级。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbf6/9194969/9a348538a4e2/LIO2-7-825-g003.jpg

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