Cuttino J T, Clark R L, Mandel S R, Webster W P, Jaques P F
Invest Radiol. 1978 Jul-Aug;13(4):328-33. doi: 10.1097/00004424-197807000-00010.
Intrarenal microlymphatic filling was observed during a microangiographic and histologic study of unmodified canine allograft rejection. The extent of lymphatic visualization was correlated with the pathophysiologic state of the allograft. An example of renal lymphatic visualization following arterial perfusion of a human specimen is also presented. During early rejection, as microvascular and histologic alteration became more severe, there was prominent visualization of lymphatics. However, in late rejection, as cortical necrosis developed, lymphatic filling was less evident. Lymphatic visualization following arterial perfusion during rejection depends on progressive loss of microvascular integrity, contrast extravasation and subsequent filling of lymphatics which are acting as an alternate route of drainage for the excess interstitial edema present due to immune injury.
在对未修饰的犬同种异体移植排斥反应进行微血管造影和组织学研究期间，观察到肾内微淋巴管充盈。淋巴管显影的程度与同种异体移植的病理生理状态相关。本文还展示了一例人体标本动脉灌注后肾淋巴管显影的情况。在早期排斥反应期间，随着微血管和组织学改变变得更加严重，淋巴管显影显著。然而，在晚期排斥反应中，随着皮质坏死的发展，淋巴管充盈不太明显。排斥反应期间动脉灌注后的淋巴管显影取决于微血管完整性的逐渐丧失、造影剂外渗以及随后淋巴管的充盈，淋巴管作为免疫损伤导致的过量间质水肿的替代引流途径。
