Institute of Neonatology, Belgrade, Serbia.
Acta Clin Croat. 2021 Dec;60(4):651-656. doi: 10.20471/acc.2021.60.04.12.
Germinal matrix-intraventricular brain hemorrhage is mostly found in preterm neonates, but may also occur in term neonates. The aim of this study was to analyze the prevalence and severity of this type of hemorrhage in moderate and late preterm and early term neonates with intrauterine growth restriction. In the prospective analysis, 100 newborns were examined, i.e. 70 with intrauterine growth restriction and 30 as a control group. Study subjects were neonates from 32 0/7 to 38 6/7 gestational weeks. Body weight, body length, head circumference and ponderal index at birth were analyzed. Hemorrhage was assessed by cranial ultrasound using Papile classification. Out of 70 neonates with intrauterine growth restriction, germinal matrix-intraventricular hemorrhage was not found in 36 (51.43%) neonates, 31 (44.29%) had hemorrhage grade 1, and three (4.29%) had hemorrhage grade 2, which was statistically significant (p<0.001) in relation to the control group. There were no neonates with hemorrhage grade 3 or 4. The predominant type of germinal matrix-intraventricular hemorrhage in the intrauterine growth restriction group was hemorrhage grade 1. Germinal matrix-intraventricular hemorrhage was more often present in the intrauterine growth restricted neonates than in the control group.
脑室内-脑室外出血主要发生在早产儿中，但也可发生在足月儿中。本研究旨在分析宫内生长受限的中晚期早产儿和早期足月儿的这种类型出血的发生率和严重程度。在前瞻性分析中，检查了 100 名新生儿，即 70 名宫内生长受限新生儿和 30 名对照组新生儿。研究对象为胎龄 32 0/7 至 38 6/7 周的新生儿。分析了出生时的体重、身长、头围和体重指数。通过头颅超声Papile 分类评估出血情况。在 70 名宫内生长受限的新生儿中，36 名（51.43%）新生儿未发现脑室内-脑室外出血，31 名（44.29%）新生儿为 1 级出血，3 名（4.29%）新生儿为 2 级出血，与对照组相比差异有统计学意义（p<0.001）。没有 3 级或 4 级出血的新生儿。宫内生长受限组脑室内-脑室外出血的主要类型为 1 级出血。与对照组相比，宫内生长受限的新生儿更易发生脑室内-脑室外出血。
