Zhou Da-An, Xu Kai, Zhao Xiaobin, Chen Qian, Sang Feng, Fan Di, Su Li, Zhang Zhanjun, Ai Lin, Chen Yaojing
Department of Rehabilitation, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
School of Artificial Intelligence, Beijing Normal University, Beijing, China.
Front Aging Neurosci. 2022 Jun 6;14:788567. doi: 10.3389/fnagi.2022.788567. eCollection 2022.
Increased amyloid burden and decreased glucose metabolism are important characteristics of Alzheimer's disease (AD), but their spatial distribution and hierarchical clustering organization are still poorly understood. In this study, we explored the distribution and clustering organization of amyloid and glucose metabolism based on F-florbetapir and F-fluorodeoxyglucose PET data from 68 AD patients and 20 cognitively normal individuals. We found that: (i) cortical regions with highest florbetapir binding were the regions with high glucose metabolism; (ii) the percentage changes of amyloid deposition were greatest in the frontal and temporal areas, and the hypometabolism was greatest in the parietal and temporal areas; (iii) brain areas can be divided into three hierarchical clusters by amyloid and into five clusters by metabolism using a hierarchical clustering approach, indicating that adjacent regions are more likely to be grouped into one sub-network; and (iv) there was a significant positive correlation in any pair of amyloid-amyloid and metabolism-metabolism sub-networks, and a significant negative correlation in amyloid-metabolism sub-networks. This may suggest that the influence forms and brain regions of AD on different pathological markers may not be synchronous, but they are closely related.
淀粉样蛋白负荷增加和葡萄糖代谢降低是阿尔茨海默病（AD）的重要特征，但其空间分布和层次聚类组织仍知之甚少。在本研究中，我们基于68例AD患者和20名认知正常个体的F- Florbetapir和F-氟脱氧葡萄糖PET数据，探索了淀粉样蛋白和葡萄糖代谢的分布及聚类组织。我们发现：（i）Florbetapir结合最高的皮质区域是葡萄糖代谢高的区域；（ii）淀粉样蛋白沉积的百分比变化在额叶和颞叶区域最大，而代谢减退在顶叶和颞叶区域最大；（iii）使用层次聚类方法，脑区可按淀粉样蛋白分为三个层次聚类，按代谢分为五个聚类，这表明相邻区域更有可能被归为一个子网络；（iv）在任何一对淀粉样蛋白-淀粉样蛋白和代谢-代谢子网络之间存在显著正相关，而在淀粉样蛋白-代谢子网络之间存在显著负相关。这可能表明AD对不同病理标志物的影响形式和脑区可能不同步，但它们密切相关。
