Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 11300, Vietnam.
Division of Chemical Engineering and Materials Science, Ewha Womans University, Seoul 03760, Korea.
Biosensors (Basel). 2022 Jun 15;12(6):420. doi: 10.3390/bios12060420.
To date, a large number of photosensitizers (PS) have introduced heavy atoms to improve the ISC process and O generation. However, they often show low efficiency in hypoxic conditions, aggregate states, and turn-off PDT in the dark. Besides that, the toxicity of heavy metals is also concerned. Therefore, we developed lysosome-targeted heavy-metal-free PS ( and ) based on thionated naphthalimide for hypoxic cancer photodynamic therapy (PDT), not only under white light but also in the dark via thermal-induced O generation. AIEgen ( and ) were prepared for studying the PDT action of PSs ( and ) in lysosome and aggregate state. We also examined the photophysical properties of AIEgen ( and ) and PS ( and ) by UV-vis absorption, fluorescent emission spectra, and theoretical calculations.
迄今为止，已经有大量的光敏剂（PS）引入重金属原子以提高 ISC 过程和 O 生成效率。然而，它们在缺氧条件下、聚集状态下以及黑暗中关闭 PDT 时往往效率低下。此外，重金属的毒性也令人关注。因此，我们开发了基于硫代萘酰亚胺的溶酶体靶向无重金属 PS（和），用于缺氧癌症光动力治疗（PDT），不仅可以在白光下，还可以在黑暗中通过热诱导的 O 生成。AIEgen（和）被制备用于研究 PS（和）在溶酶体和聚集状态下的 PDT 作用。我们还通过紫外可见吸收光谱、荧光发射光谱和理论计算研究了 AIEgen（和）和 PS（和）的光物理性质。
