Hsieh Meng-Chieh, Chien Cheng-Hao, Chang Cheng-Chung, Chang Ta-Chau
Graduate Institute of Biomedical Engineering, National Chung Hsing University, 250 Kuo Kuang Road, Taichung, 402, Taiwan, ROC.
J Mater Chem B. 2013 May 14;1(18):2350-2357. doi: 10.1039/c3tb00345k. Epub 2013 Mar 26.
A binary molecule can self-assemble to form fluorescent organic nanoparticles (FONs) based on the Aggregation-Induced Emission Enhancement (AIEE) property and subsequently, presents an efficient fluorescence resonance energy transfer (FRET) to generate singlet oxygen under linear and nonlinear light sources. Biologically, this FON-photosensitizer is much more phototoxic to cancer cells than to normal cells without significant dark toxicity. Eventually, a new approach, called FON FRET-PDT or AIEE FRET-PDT, to promote the PDT effect is expected.
二元分子可基于聚集诱导发光增强（AIEE）特性自组装形成荧光有机纳米颗粒（FONs），随后，在线性和非线性光源下呈现高效的荧光共振能量转移（FRET）以产生活性单线态氧。从生物学角度来看，这种FON光敏剂对癌细胞的光毒性远高于正常细胞，且无明显暗毒性。最终，有望开发出一种名为FON FRET-PDT或AIEE FRET-PDT的新方法来增强光动力疗法（PDT）的效果。
