School of Electrical Engineering, Shandong University, Jinan, China.
School of Goertek Technology and Industry, Weifang University, Weifang, China.
Artif Organs. 2022 Nov;46(11):2159-2170. doi: 10.1111/aor.14348. Epub 2022 Jul 7.
Speed modulation of blood pumps has been proved to help restore vascular pulsatility and implemented clinically during treatment for cardiac failure. However, its effect on blood trauma has not been studied thoroughly.
In this paper, we study the flow field of an axial pump FW-X under the modes of co-pulse, counter pulse, and constant speed to evaluate the blood trauma. Based on the coupling model of cardiovascular systems and axial blood pump, aortic pressure and the pump flow were obtained and applied as the boundary conditions at the pump outlet and inlet. The level of shear stress and hemolysis index were derived from computational fluid dynamics (CFD) simulation.
Results showed that the constant speed mode had the lowest shear stress level and hemolytic index at the expense of diminished pulsatility. Compared with the constant speed mode, the hemolysis index of co-pulse and counter pulse mode was higher, but it was helpful to restore vascular pulsatility.
This method can be easily incorporated in the in vitro testing phase to analyze and decrease a pump's trauma before animal experimentation, thereby reducing the cost of blood pump development.
血液泵的速度调节已被证明有助于恢复血管搏动，并在心力衰竭治疗期间临床实施。然而，其对血液创伤的影响尚未得到充分研究。
本文研究了 FW-X 轴流泵在共脉冲、反脉冲和恒速模式下的流场，以评估血液创伤。基于心血管系统和轴流血泵的耦合模型，获得了主动脉压力和泵流量，并将其作为泵出口和入口的边界条件。从计算流体动力学（CFD）模拟中得出剪切应力和溶血指数。
结果表明，恒速模式的剪切应力水平和溶血指数最低，但搏动性降低。与恒速模式相比，共脉冲和反脉冲模式的溶血指数较高，但有助于恢复血管搏动。
该方法可在体外测试阶段轻松采用，以在动物实验前分析和降低泵的创伤，从而降低血泵开发成本。
