呼吸道上皮细胞：不仅仅是真菌感染的物理屏障

Respiratory Epithelial Cells: More Than Just a Physical Barrier to Fungal Infections.

作者信息

Barros Bianca C S C, Almeida Bruna R, Barros Debora T L, Toledo Marcos S, Suzuki Erika

机构信息

Laboratory of Applied Toxinology, Center of Toxins, Immune-Response and Cell Signaling (CeTICS), Butantan Institute, São Paulo 05503-900, SP, Brazil.

Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, Universidade Federal de São Paulo, Ed. Antonio C. M. Paiva, São Paulo 04023-062, SP, Brazil.

出版信息

J Fungi (Basel). 2022 May 24;8(6):548. doi: 10.3390/jof8060548.

DOI:10.3390/jof8060548

PMID:35736031

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9225092/

Abstract

The respiratory epithelium is highly complex, and its composition varies along the conducting airways and alveoli. In addition to their primary function in maintaining the respiratory barrier and lung homeostasis for gas exchange, epithelial cells interact with inhaled pathogens, which can manipulate cell signaling pathways, promoting adhesion to these cells or hosting tissue invasion. Moreover, pathogens (or their products) can induce the secretion of chemokines and cytokines by epithelial cells, and in this way, these host cells communicate with the immune system, modulating host defenses and inflammatory outcomes. This review will focus on the response of respiratory epithelial cells to two human fungal pathogens that cause systemic mycoses: and . Some of the host epithelial cell receptors and signaling pathways, in addition to fungal adhesins or other molecules that are responsible for fungal adhesion, invasion, or induction of cytokine secretion will be addressed in this review.

摘要

呼吸道上皮高度复杂，其组成沿传导气道和肺泡而变化。除了在维持呼吸屏障和肺内环境稳定以进行气体交换方面的主要功能外，上皮细胞还与吸入的病原体相互作用，病原体可操纵细胞信号通路，促进对这些细胞的黏附或引发组织侵袭。此外，病原体（或其产物）可诱导上皮细胞分泌趋化因子和细胞因子，通过这种方式，这些宿主细胞与免疫系统进行沟通，调节宿主防御和炎症反应。本综述将聚焦呼吸道上皮细胞对两种引起系统性真菌病的人类真菌病原体的反应：和。本综述还将探讨一些宿主上皮细胞受体和信号通路，以及负责真菌黏附、侵袭或诱导细胞因子分泌的真菌黏附素或其他分子。