Department of General and Clinical Pathology, Faculty of Veterinary Medicine, Trakia University, Students Campus, 6000 Stara Zagora, Bulgaria.
Toxins (Basel). 2022 May 30;14(6):380. doi: 10.3390/toxins14060380.
A review of the carcinogenic effects of ochratoxin A (OTA) on various tissues and internal organs in laboratory and farm animals is made. Suggestions are made regarding how to recognize and differentiate the common spontaneous neoplastic changes characteristic for advanced age and the characteristic neoplasia in different tissues and organs in laboratory animals/poultry exposed to OTA. The synergistic effects of OTA together with its natural combination of penicillic acid are also investigated regarding possible carcinogenic effects. The malignancy and the target location of OTA-induced neoplasia is studied. The sex-differences of such neoplasia are investigated in the available literature. The time of appearance of the first neoplasia is investigated in long-term carcinogenic studies with OTA-treated animals. The possibility of target feed additives or herbs to counteract the toxic and carcinogenic effects of OTA is studied in the available literature. Some effective manners of prophylaxis and/or prevention against OTA contamination of feedstuffs/foods or animal production are suggested. The suitability of various laboratory animals to serve as experimental model for humans with regard to OTA-induced tumorigenesis is investigated.
本文综述了赭曲霉毒素 A（OTA）在实验室和农场动物的各种组织和内脏器官中的致癌作用。文中提出了如何识别和区分暴露于 OTA 的老年动物和不同组织器官中常见的自发性肿瘤变化以及特征性肿瘤的建议。还研究了 OTA 与其天然组合青霉素酸的协同作用对可能的致癌作用的影响。研究了 OTA 诱导的肿瘤的恶性程度和靶器官位置。在现有的文献中研究了这种肿瘤的性别差异。在 OTA 处理动物的长期致癌研究中，研究了首次出现肿瘤的时间。在现有的文献中研究了靶饲料添加剂或草药是否可以抵消 OTA 的毒性和致癌作用。本文提出了一些有效的方法来预防和/或防止饲料/食品或动物生产中 OTA 的污染。还研究了各种实验室动物作为人类 OTA 诱导肿瘤发生的实验模型的适用性。
