Murthy M S, Travis J D, Scanlon E F
J Surg Oncol. 1987 May;35(1):44-9. doi: 10.1002/jso.2930350111.
The factors influencing the growth and metastatic behavior of experimental animal tumors are examined. 10(4) TA3Ha cells were injected intraperitoneally, intravenously, subcutaneously into the flank, and subcutaneously into the tail tissues of syngeneic strain A mice. The tumor takes from these injections were 50/50 (100%), 1/10 (10%), 10/10 (100%), and 7/12 (60%), respectively. The frequency of lung metastasis from these sites was 0, 100, 50, and 100%, respectively. At the time of host death, the flank and tail tumors were, respectively, 2.2 +/- 0.5 cm (geometric mean diameter) and 1.2 +/- 0.3 cm in the TA3Ha and 0.9 +/- 0.1 cm and 0.4 +/- 0.1 cm in the L1210 systems. TA3Ha tumors metastasized regularly to the lymph nodes but the L1210 tumors seldom metastasized to the lymph nodes. Tail implants of TA3Ha tumors behaved similarly in the athymic nude mice and strain A mice. TA3Ha cells inoculated into the Millipore chambers and maintained in mice for greater than 150 days were viable and able to form tumors. The results demonstrate that the anatomic location of the tumor affects the growth and metastatic behavior of the tumors, and that the tumors of different histologic origin metastasize differently even when grown in corresponding locations.
研究了影响实验动物肿瘤生长和转移行为的因素。将10(4)个TA3Ha细胞分别经腹腔、静脉、皮下注射到同基因A系小鼠的胁腹和尾部组织。这些注射产生肿瘤的成功率分别为50/50(100%)、1/10(10%)、10/10(100%)和7/12(60%)。这些部位发生肺转移的频率分别为0、100%、50%和100%。在宿主死亡时，TA3Ha小鼠胁腹和尾部肿瘤的几何平均直径分别为2.2±0.5 cm和1.2±0.3 cm，L1210小鼠的分别为0.9±0.1 cm和0.4±0.1 cm。TA3Ha肿瘤经常转移至淋巴结，而L1210肿瘤很少转移至淋巴结。TA3Ha肿瘤的尾部植入物在无胸腺裸鼠和A系小鼠中的表现相似。接种到微孔小室并在小鼠体内维持超过150天的TA3Ha细胞仍具有活力并能够形成肿瘤。结果表明，肿瘤的解剖位置会影响肿瘤的生长和转移行为，并且不同组织学起源的肿瘤即使在相应位置生长时转移方式也不同。
