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西红花酸的抗氧化和抗炎作用评估。

An evaluation on potential anti-oxidant and anti-inflammatory effects of Crocin.

机构信息

Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

Cancer Biology Research Group, Faculty of Medicine Institute of Biotechnology (FMB-IBTEC) Sao Paulo State University (UNESP), Brazil.

出版信息

Biomed Pharmacother. 2022 Sep;153:113297. doi: 10.1016/j.biopha.2022.113297. Epub 2022 Jun 20.

DOI:10.1016/j.biopha.2022.113297
PMID:35738178
Abstract

Crocin, an active ingredient derived from saffron, is one of the herbal components that has recently been considered by researchers. Crocin has been shown to have many anti-inflammatory and antioxidant properties, and therefore can be used to treat various diseases. It has been shown that Crocin has a positive effect on the prevention and treatment of cardiovascular disease, cancer, diabetes, and kidney disease. In addition, the role of this substance in COVID-19 pandemic has been identified. In this review article, we tried to have a comprehensive review of the antioxidant and anti-inflammatory effects of Crocin in different diseases and different tissues. In conclusion, Crocin may be helpful in pathological conditions that are associated with inflammation and oxidative stress.

摘要

西红花苷,一种从藏红花中提取的活性成分,是最近受到研究人员关注的草药成分之一。西红花苷具有许多抗炎和抗氧化特性,因此可用于治疗各种疾病。研究表明,西红花苷对预防和治疗心血管疾病、癌症、糖尿病和肾脏疾病有积极作用。此外,还确定了这种物质在 COVID-19 大流行中的作用。在这篇综述文章中,我们试图全面回顾西红花苷在不同疾病和不同组织中的抗氧化和抗炎作用。总之,西红花苷可能对与炎症和氧化应激相关的病理状况有帮助。

相似文献

1
An evaluation on potential anti-oxidant and anti-inflammatory effects of Crocin.西红花酸的抗氧化和抗炎作用评估。
Biomed Pharmacother. 2022 Sep;153:113297. doi: 10.1016/j.biopha.2022.113297. Epub 2022 Jun 20.
2
Immunomodulatory and anti-inflammatory potential of crocin in COVID-19 treatment.藏红花素在 COVID-19 治疗中的免疫调节和抗炎潜力。
J Food Biochem. 2021 May;45(5):e13718. doi: 10.1111/jfbc.13718. Epub 2021 Apr 4.
3
Crocin reverses unilateral renal ischemia reperfusion injury-induced augmentation of oxidative stress and toll like receptor-4 activity.西红花苷可逆转单侧肾缺血再灌注损伤引起的氧化应激和 Toll 样受体-4 活性增强。
Environ Toxicol Pharmacol. 2018 Apr;59:182-189. doi: 10.1016/j.etap.2018.03.017. Epub 2018 Mar 27.
4
Therapeutic effects of Crocin in autoimmune diseases: A review.西红花苷在自身免疫性疾病中的治疗作用:综述。
Biofactors. 2019 Nov;45(6):835-843. doi: 10.1002/biof.1557. Epub 2019 Aug 20.
5
In silico evaluation of food-derived carotenoids against SARS-CoV-2 drug targets: Crocin is a promising dietary supplement candidate for COVID-19.基于计算机的食物源类胡萝卜素对 SARS-CoV-2 药物靶标的评估:藏红花酸是一种有前景的 COVID-19 膳食补充剂候选物。
J Food Biochem. 2022 Sep;46(9):e14219. doi: 10.1111/jfbc.14219. Epub 2022 May 11.
6
Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention.西红花中的藏红花酸和藏红花素在癌症化疗和化学预防中的作用。
Anticancer Agents Med Chem. 2019;19(1):38-47. doi: 10.2174/1871520619666181231112453.
7
Bioactivity assessment and toxicity of crocin: a comprehensive review.西红花苷的生物活性评价及毒性研究:全面综述。
Food Chem Toxicol. 2014 Feb;64:65-80. doi: 10.1016/j.fct.2013.11.016. Epub 2013 Nov 22.
8
Crocin modulates IL-4/IL-13 signaling and ameliorates experimentally induced allergic airway asthma in a murine model.藏红花素调节白细胞介素-4/白细胞介素-13信号通路,并改善小鼠模型中实验性诱导的过敏性气道哮喘。
Int Immunopharmacol. 2017 Sep;50:305-312. doi: 10.1016/j.intimp.2017.07.012. Epub 2017 Jul 21.
9
Crocin Inhibits Apoptosis and Astrogliosis of Hippocampus Neurons Against Methamphetamine Neurotoxicity via Antioxidant and Anti-inflammatory Mechanisms.藏红花酸通过抗氧化和抗炎机制抑制海马神经元对抗甲基苯丙胺神经毒性的细胞凋亡和星形胶质细胞增生。
Neurochem Res. 2018 Dec;43(12):2252-2259. doi: 10.1007/s11064-018-2644-2. Epub 2018 Sep 27.
10
Crocin attenuates oxidative and inflammatory stress-related periodontitis in cardiac tissues in rats.西红花苷可减轻大鼠心脏组织氧化应激和炎症反应相关的牙周炎。
Adv Clin Exp Med. 2021 May;30(5):517-524. doi: 10.17219/acem/133753.

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Effects of Nrf-2/HO-1, NF-κB/Cox-2/TLR-4, and Bax/Bcl-2/caspase-3 pathways in alleviating azithromycin-induced cardiotoxicity in rats: Potential cardioprotective role of crocin.Nrf-2/HO-1、NF-κB/Cox-2/TLR-4和Bax/Bcl-2/caspase-3信号通路在减轻阿奇霉素诱导的大鼠心脏毒性中的作用:西红花苷的潜在心脏保护作用
Iran J Basic Med Sci. 2025;28(10):1335-1343. doi: 10.22038/ijbms.2025.83518.18069.
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Evaluation of therapeutic effects of Crocin in patients with polycystic ovary syndrome: A randomized Double-Blind clinical trial.西红花苷对多囊卵巢综合征患者的治疗效果评估:一项随机双盲临床试验。
J Pharm Health Care Sci. 2025 Aug 8;11(1):69. doi: 10.1186/s40780-025-00432-7.
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The impacts of natural polyphenols and exercise alone or together on microRNAs and angiogenic signaling.
天然多酚和运动单独或共同对微小RNA和血管生成信号的影响。
Front Pharmacol. 2025 Jun 24;16:1560305. doi: 10.3389/fphar.2025.1560305. eCollection 2025.
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Enhancing Neuroprotection Through Exercise: The Synergistic Effects of Bioactive Plant Compounds Via the CREB-BDNF Signaling Pathway.通过运动增强神经保护作用:生物活性植物化合物经由CREB-BDNF信号通路的协同效应
J Neuroimmune Pharmacol. 2025 Jun 30;20(1):69. doi: 10.1007/s11481-025-10228-z.
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Effects of Conocarpus lancifolius and crocin on superoxide dismutase and protein kinase B genes and protein expressions in diabetic rats.海榄雌和藏红花素对糖尿病大鼠超氧化物歧化酶及蛋白激酶B基因和蛋白表达的影响。
PLoS One. 2025 Jun 26;20(6):e0326676. doi: 10.1371/journal.pone.0326676. eCollection 2025.
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Treatment with crocin attenuates cardiac metabolic disturbances and subsequent inflammation in streptozotocin-induced diabetes.西红花苷治疗可减轻链脲佐菌素诱导的糖尿病中的心脏代谢紊乱及随后的炎症反应。
Mol Cell Biochem. 2025 Jun 3. doi: 10.1007/s11010-025-05320-0.
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Significance feature of saffron on testicular histomorphometry and expression profile of antioxidant enzymes in mice with induced multiple sclerosis: an in-vivo study.藏红花对诱导性多发性硬化症小鼠睾丸组织形态计量学及抗氧化酶表达谱的显著影响:一项体内研究。
J Mol Histol. 2025 Jun 2;56(3):181. doi: 10.1007/s10735-025-10444-0.
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Cosmeceutical application of extracts from the flowers, stems, and leaves of grown at different altitudes.不同海拔地区种植的[植物名称]花、茎和叶提取物的药妆应用。 注:原文中“grown at different altitudes”前缺少具体植物名称,这里补充了[植物名称]以便译文更完整通顺。你可根据实际情况替换。
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Crocin promotes ferroptosis in gastric cancer via the Nrf2/GGTLC2 pathway.西红花苷通过Nrf2/GGTLC2途径促进胃癌细胞铁死亡。
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