Department of Fundamental and Community Nursing, School of Nursing, Nanjing Medical University, Nanjing, 211166, China.
Department of Nutrition and Food Safety, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
BMC Gastroenterol. 2022 Jun 24;22(1):308. doi: 10.1186/s12876-022-02386-8.
TEADs are critical transcription factors that participate in the Hippo pathway. Evidence indicates the promotion role of TEADs in cancer progression. However, the role of TEADs and the expression patterns in gastric cancer remains unclear. In this study, we evaluated the expression levels of TEADs in gastric cancer samples, and the clinical outcomes of patients with high TEADs expression were observed. Co-expression and interaction analysis as well as functional enrichment analysis were further conducted to determine the potential role of TEADs in gastric cancer. These results suggested TEADs may serve as the prognostic biomarkers or therapeutic targets for gastric cancer. However, more studies are warranted to verify our findings and promote the application in gastric cancer patients.
TEADs 是参与 Hippo 通路的关键转录因子。有证据表明 TEADs 在癌症进展中起促进作用。然而，TEADs 在胃癌中的作用和表达模式仍不清楚。在这项研究中，我们评估了 TEADs 在胃癌样本中的表达水平，并观察了高 TEADs 表达患者的临床结局。进一步进行了共表达和相互作用分析以及功能富集分析，以确定 TEADs 在胃癌中的潜在作用。这些结果表明 TEADs 可能成为胃癌的预后生物标志物或治疗靶点。然而，需要更多的研究来验证我们的发现，并促进其在胃癌患者中的应用。
