Patil Priyanka P, Khanal Pukar, Patil Vishal S, Charla Rajitha, Harish Darasaguppe R, Patil Basanagouda M, Roy Subarna
KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research (KAHER), Belagavi 590010, Karnataka, India.
Indian Council of Medical Research, National Institute of Traditional Medicine, Belagavi 590010, Karnataka, India.
Antioxidants (Basel). 2022 May 31;11(6):1094. doi: 10.3390/antiox11061094.
Doxorubicin is a widely used chemotherapeutic agent that causes oxidative stress leading to cardiotoxicity, hepatotoxicity, and nephrotoxicity. In contrast, L. has been recorded as an anticancer agent and found to be protective against multiple chemical-induced organ injuries, including heart, liver, and kidney injuries. The present study investigated the possible role of extracts from beans for organ-protective effects in doxorubicin-induced toxicity in mice bearing Ehrlich ascites carcinoma (EAC).
After survival analysis in rodents, cocoa bean extract (COE) was investigated for its efficacy against EAC-induced carcinoma and its organ-protective effect against doxorubicin-treated mice with EAC-induced carcinoma.
Significant reductions in EAC and doxorubicin-induced alterations were observed in mice administered the COE, either alone or in combination with doxorubicin. Furthermore, COE treatment significantly increased the mouse survival time, life span percentage, and antioxidant defense system. It also significantly improved cardiac, hepatic, and renal function biomarkers and markers for oxidative stress, and it also reduced doxorubicin-induced histopathological changes.
COE acted against doxorubicin-induced organ toxicity; potent antioxidant and anticancer activities were also reflected by the COE itself. The COE may therefore serve as an adjuvant nutraceutical in cancer chemotherapy.
阿霉素是一种广泛使用的化疗药物，会引起氧化应激，导致心脏毒性、肝毒性和肾毒性。相比之下，L.已被记录为一种抗癌剂，并被发现对多种化学诱导的器官损伤具有保护作用，包括心脏、肝脏和肾脏损伤。本研究调查了豆提取物对荷艾氏腹水癌（EAC）小鼠阿霉素诱导毒性的器官保护作用的可能作用。
在对啮齿动物进行生存分析后，研究了可可豆提取物（COE）对EAC诱导的癌症的疗效及其对阿霉素治疗的EAC诱导癌症小鼠的器官保护作用。
单独或与阿霉素联合给药COE的小鼠中，观察到EAC和阿霉素诱导的改变显著减少。此外，COE治疗显著延长了小鼠的存活时间、寿命百分比和抗氧化防御系统。它还显著改善了心脏、肝脏和肾脏功能生物标志物以及氧化应激标志物，并且还减少了阿霉素诱导的组织病理学变化。
COE对阿霉素诱导的器官毒性有作用；COE本身也反映出强大的抗氧化和抗癌活性。因此，COE可作为癌症化疗中的辅助营养保健品。
