Department of Pathophysiology, Key Laboratory of Ministry of Education for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Biomolecules. 2022 Jun 4;12(6):785. doi: 10.3390/biom12060785.
Zinc is essential for human growth and development. As a trace nutrient, zinc plays important roles in numerous signal transduction pathways involved in distinct physiologic or pathologic processes. Protein phosphorylation is a posttranslational modification which regulates protein activity, degradation, and interaction with other molecules. Protein kinases (PKs) and phosphatases (PPs), with their effects of adding phosphate to or removing phosphate from certain substrates, are master regulators in controlling the phosphorylation of proteins. In this review, we summarize the disturbance of zinc homeostasis and role of zinc disturbance in regulating protein kinases and protein phosphatases in neurodegenerative diseases, with the focus of that in Alzheimer's disease, providing a new perspective for understanding the mechanisms of these neurologic diseases.
锌对于人类的生长和发育是必不可少的。作为一种痕量营养素，锌在众多信号转导途径中发挥重要作用，这些途径涉及不同的生理或病理过程。蛋白质磷酸化是一种翻译后修饰，它可以调节蛋白质的活性、降解和与其他分子的相互作用。蛋白激酶（PKs）和磷酸酶（PPs）通过在某些底物上添加或去除磷酸基团来发挥作用，是控制蛋白质磷酸化的主要调节因子。在这篇综述中，我们总结了锌稳态的紊乱以及锌紊乱在调节神经退行性疾病中的蛋白激酶和蛋白磷酸酶中的作用，重点是阿尔茨海默病，为理解这些神经疾病的机制提供了新的视角。
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