Laboratory of Chronobiology, Charité Universitätsmedizin Berlin, Hessische Str. 3-4, 10115 Berlin, Germany.
FEBS Lett. 2011 May 20;585(10):1393-9. doi: 10.1016/j.febslet.2011.02.038. Epub 2011 Mar 3.
Posttranslational modifications of circadian oscillator components are crucial for the generation of circadian rhythms. Among those phosphorylation plays key roles ranging from regulating degradation, complex formation, subcellular localization and activity. Although most of the known clock proteins are phosphoproteins in vivo, a comprehensive view about the regulation of clock protein phosphorylation is still missing. Here, we review our current knowledge about the role of clock protein phosphorylation and its regulation by kinases and phosphatases in eukaryotes with a major focus on the mammalian circadian clock.
生物钟振荡器组件的翻译后修饰对于产生昼夜节律至关重要。在这些翻译后修饰中，磷酸化起着关键作用，从调节降解、复合物形成、亚细胞定位和活性等方面进行调节。尽管大多数已知的生物钟蛋白在体内都是磷酸化蛋白，但关于生物钟蛋白磷酸化的调节仍然缺乏全面的认识。在这里，我们综述了真核生物中生物钟蛋白磷酸化及其由激酶和磷酸酶调节的作用的最新知识，重点是哺乳动物生物钟。
