Kurosawa M
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
J Pharmacol Toxicol Methods. 1994 Jun;31(3):135-9. doi: 10.1016/1056-8719(94)90075-2.
Phosphorylation state of cellular proteins reflects the balance between the activities of protein kinases and phosphoprotein phosphatases. The increase in cellular protein phosphorylation in response to stimuli can be achieved by either activating protein kinases and/or promoting the turnover of the protein phosphatases. This review will summarize current knowledge of the control of phosphorylation and dephosphorylation of protein in cells.
细胞蛋白质的磷酸化状态反映了蛋白激酶和磷蛋白磷酸酶活性之间的平衡。细胞蛋白质磷酸化对刺激的增加可通过激活蛋白激酶和/或促进蛋白质磷酸酶的周转来实现。本综述将总结目前关于细胞中蛋白质磷酸化和去磷酸化调控的知识。
