Department of Ophthalmology, John A. Moran Eye Center, University of Utah, 65 Mario Capecchi Dr., Salt Lake City, UT 84132, USA.
Cells. 2022 Jun 17;11(12):1951. doi: 10.3390/cells11121951.
Retinopathy of prematurity (ROP) is a leading cause of vision impairment and blindness in premature infants. Oxidative stress is implicated in its pathophysiology. NADPH oxidase (NOX), a major enzyme responsible for reactive oxygen species (ROS) generation in endothelial cells, has been studied for its involvement in physiologic and pathologic angiogenesis. Erythropoietin (EPO) has gained interest recently due to its tissue protective and angiogenic effects, and it has been shown to act as an antioxidant. In this review, we summarize studies performed over the last five years regarding the role of various NOXs in physiologic and pathologic angiogenesis. We also discuss the effect of EPO in tissue and vasoprotection, and the intersection of EPO and NOX-mediated oxidative stress in angiogenesis and the pathophysiology of ROP.
早产儿视网膜病变（ROP）是早产儿视力损害和失明的主要原因。氧化应激与ROP 的病理生理学有关。NADPH 氧化酶（NOX）是内皮细胞中产生活性氧（ROS）的主要酶，其在生理性和病理性血管生成中的作用已被研究。促红细胞生成素（EPO）因其组织保护和血管生成作用而受到关注，并且已被证明具有抗氧化作用。在这篇综述中，我们总结了过去五年关于各种 NOX 在生理性和病理性血管生成中的作用的研究。我们还讨论了 EPO 在组织和血管保护中的作用，以及 EPO 和 NOX 介导的氧化应激在血管生成和 ROP 病理生理学中的相互作用。
