Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.
Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Cells. 2022 Jun 19;11(12):1970. doi: 10.3390/cells11121970.
TNF and LTα are structurally related cytokines of the TNF superfamily. Their genes are located in close proximity to each other and to the gene within the TNF/LT locus inside MHC. Unlike , transcription of and of is tightly controlled, with the gene being an immediate early gene that is rapidly induced in response to various inflammatory stimuli. Genes of the TNF/LT locus play a crucial role in lymphoid tissue organogenesis, although some aspects of their specific contribution remain controversial. Here, we present new findings and discuss the distinct contribution of TNF produced by ILC3 cells to Peyer's patch organogenesis.
TNF 和 LTα 是 TNF 超家族中结构相关的细胞因子。它们的基因彼此紧密相邻，位于 MHC 内的 TNF/LT 基因座内。与 TNF 不同， 和 的转录受到严格控制， 基因是一种即刻早期基因，可迅速响应各种炎症刺激而被诱导。TNF/LT 基因座的基因在淋巴组织器官发生中起着至关重要的作用，尽管它们的具体贡献的某些方面仍存在争议。在这里，我们提出了新的发现，并讨论了 ILC3 细胞产生的 TNF 对派伊尔氏斑器官发生的独特贡献。
