Micheli Gioacchino, Camilloni Giorgio
Istituto di Biologia e Patologia Molecolari CNR, Università Sapienza, P.le A. Moro 5, 00185 Roma, Italy.
Dipartimento di Biologia e Biotecnologie "C. Darwin", Università Sapienza, P.le A. Moro 5, 00185 Roma, Italy.
Biology (Basel). 2022 Jun 20;11(6):941. doi: 10.3390/biology11060941.
Gene duplication is considered one of the most important events that determine the evolution of genomes. However, the neo-duplication condition of a given gene is particularly unstable due to recombination events. Several mechanisms have been proposed to justify this step. In this "opinion article" we propose a role for intron sequences in stabilizing gene duplication by limiting and reducing the identity of the gene sequence between the two duplicated copies. A review of the topic and a detailed hypothesis are presented.
基因复制被认为是决定基因组进化的最重要事件之一。然而，由于重组事件，特定基因的新复制状态特别不稳定。已经提出了几种机制来解释这一步骤。在这篇“观点文章”中，我们提出内含子序列在通过限制和降低两个复制拷贝之间基因序列的一致性来稳定基因复制方面的作用。本文对该主题进行了综述并提出了详细的假设。
