Giubelan Lucian, Stanciu Ilona, Ilie Cristina, Pădureanu Vlad
Department of Infectious Diseases, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Department of Infectious Diseases, Victor Babes Hospital of Infectious Diseases and Pulmonology, 200515 Craiova, Romania.
Healthcare (Basel). 2022 May 25;10(6):982. doi: 10.3390/healthcare10060982.
The aim of this paper is to present a case of COVID-19 in a newly diagnosed HIV-infected, severely immunodepressed patient with a long persistence of positive RT-PCR for RNA SARS-CoV-2. Indirect data suggests that viable virus persisted for a long time in the absence of an adequate defense of the host. Improved immunity after starting antiretroviral treatment was not associated with an increased inflammatory reaction as regarding the infection due to the coronavirus and, apparently, was the main factor to control the infection. Remdesivir used to combat the SARS-CoV-2 infection had no immediate effect on the recorded cycle-threshold.
本文旨在介绍一例新冠病毒病病例，患者为新诊断的艾滋病毒感染且严重免疫抑制，其新冠病毒核糖核酸逆转录聚合酶链式反应（RT-PCR）长时间呈阳性。间接数据表明，在宿主缺乏充分防御的情况下，活病毒持续存在了很长时间。开始抗逆转录病毒治疗后免疫力的改善与冠状病毒感染所致炎症反应增加无关，显然，这是控制感染的主要因素。用于对抗新冠病毒感染的瑞德西韦对记录的循环阈值没有立即影响。
