Akiyama M, Shirakawa T, Hattori N, Takahashi K, Azuma K, Totsuka M, Hayasaka H
Nihon Geka Gakkai Zasshi. 1987 Feb;88(2):138-42.
Tissue circulation of the adrenal gland which is known as antishock organ was investigated by the hydrogen clearance method in hemorrhagic and endotoxin shock using rabbits. Mean blood pressure was maintained at 35 mmHg for two hours in the hemorrhagic group, while 2mg/kg of endotoxin was injected intravenously in the endotoxin group. The data obtained were as follows: Adrenal tissue circulation and renal circulation were reduced to 40% and 14.9%, respectively in the hemorrhagic group and reduced to 69% and 48%, respectively in the endotoxin group. Plasma corticosterone concentration was significantly elevated in both groups. Plasma beta-glucuronidase was significantly elevated in both groups and most animals died within 72 hours. From these data we concluded that adrenal circulation was distributed preferentially at the sacrifice of renal circulation in the shocked state.
采用氢清除法，以家兔为实验对象，研究了被称为抗休克器官的肾上腺的组织循环情况，实验包括失血性休克和内毒素性休克。失血性休克组平均血压维持在35 mmHg达两小时，而内毒素性休克组静脉注射2mg/kg内毒素。得到的数据如下：失血性休克组肾上腺组织循环和肾循环分别降至40%和14.9%，内毒素性休克组分别降至69%和48%。两组血浆皮质酮浓度均显著升高。两组血浆β-葡萄糖醛酸酶均显著升高，且大多数动物在72小时内死亡。从这些数据我们得出结论，在休克状态下，肾上腺循环优先分配，以牺牲肾循环为代价。
