Klopman G, Macina O T
Mol Pharmacol. 1987 Apr;31(4):457-76.
The computer-automated structure evaluation (CASE) program has been applied to the evaluation of antileukemic (L1210) and toxic activities of an extensive series of 9-anilinoacridines. Major molecular fragments relevant to the respective biological endpoints were automatically generated and incorporated within equations used to estimate the degree of activity. Correlations of these activating/inactivating fragments with the biological activities are discussed.
计算机自动结构评估（CASE）程序已应用于一系列广泛的9-苯胺基吖啶的抗白血病（L1210）和毒性活性评估。与各自生物学终点相关的主要分子片段被自动生成并纳入用于估计活性程度的方程式中。讨论了这些激活/失活片段与生物活性的相关性。
