Kovacic P, Ames J R, Ryan M D
Department of Chemistry, University of Wisconsin-Milwaukee 53201.
Anticancer Drug Des. 1987 Aug;2(1):37-46.
A possible mode of action involving electron transfer is advanced for the 9-anilinoacridines. The mechanism entails formation of toxic oxy radicals which destroy the neoplasm. Cyclic voltammetry was performed on iminium type ions derived by protonation of the acridines. Reductions were generally reversible with potentials of about -0.60 V. Involvement of quinoidal metabolites is also a possibility. The relationship of electrochemical behavior to structure and physiological activity is addressed.
对于9-苯胺基吖啶，提出了一种可能涉及电子转移的作用模式。该机制需要形成破坏肿瘤的有毒氧自由基。对吖啶质子化衍生的亚胺型离子进行了循环伏安法研究。还原反应通常是可逆的，电位约为-0.60V。醌类代谢物的参与也是一种可能性。探讨了电化学行为与结构和生理活性之间的关系。
