1st Department of Pediatrics, Semmelweis University, 1083 Budapest, Hungary.
ELKH-SE Pediatrics and Nephrology Research Group, 1052 Budapest, Hungary.
Int J Mol Sci. 2022 Jun 14;23(12):6626. doi: 10.3390/ijms23126626.
It is increasingly known that Parkinson's (PD) and Alzheimer's (AD) diseases occur more frequently in patients with inflammatory gastrointestinal diseases including inflammatory bowel (IBD) or celiac disease, indicating a pathological link between them. Although epidemiological observations suggest the existence of the gut-brain axis (GBA) involving systemic inflammatory and neural pathways, little is known about the exact molecular mechanisms. Parkinson's disease 7 (PARK7/DJ-1) is a multifunctional protein whose protective role has been widely demonstrated in neurodegenerative diseases, including PD, AD, or ischemic stroke. Recent studies also revealed the importance of PARK7/DJ-1 in the maintenance of the gut microbiome and also in the regulation of intestinal inflammation. All these findings suggest that PARK7/DJ-1 may be a link and also a potential therapeutic target in gut and brain diseases. In this review, therefore, we discuss our current knowledge about PARK7/DJ-1 in the context of GBA diseases.
越来越多的研究表明，帕金森病（PD）和阿尔茨海默病（AD）等炎症性胃肠道疾病（包括炎症性肠病或乳糜泻）患者的发病率更高，这表明它们之间存在病理联系。尽管流行病学观察表明存在涉及全身炎症和神经途径的肠脑轴（GBA），但对于确切的分子机制知之甚少。帕金森病 7（PARK7/DJ-1）是一种多功能蛋白，其在包括 PD、AD 或缺血性中风在内的神经退行性疾病中的保护作用已得到广泛证实。最近的研究还揭示了 PARK7/DJ-1 在维持肠道微生物组和调节肠道炎症中的重要性。所有这些发现都表明，PARK7/DJ-1 可能是肠道和大脑疾病的联系，也是潜在的治疗靶点。因此，在这篇综述中，我们讨论了我们目前关于 GBA 疾病中 PARK7/DJ-1 的知识。
