Ferrandez-Pujante Alba, Pons-Fuster Eduardo, López-Jornet Pia
Colaborate Department Stomatology, School of Medicine, Oral Medicine University of Murcia, 30100 Murcia, Spain.
Department Anatomy Psicobiology, Faculty of Medicine, Regional Campus of International Excellence 'Campus Mare Nostrum', University of Murcia, 30100 Murcia, Spain.
J Clin Med. 2022 Jun 14;11(12):3414. doi: 10.3390/jcm11123414.
Objectives: To evaluate the efficacy of photobiomodulation (PBM) treatment in patients with xerostomia and hyposalivation and assess their quality of life over a one year of follow-up. Material and methods: A single-blind randomized controlled trial. A total of 60 patients with xerostomia were included (30 PBM cases and 30 placebo controls). Photobiomodulation was performed with a diode laser (810 nm, 6 J/cm2), while the controls underwent simulated treatment. One weekly session was carried out for a total of 6 weeks (total six sessions). The study parameters were recorded at baseline, after three and six weeks, and at one year post-treatment. Xerostomia was assessed using a salivary flow visual analog scale (VAS) and the Xerostomia Inventory (XI). The Hospital Anxiety and Depression (HAD) scale, Oral Health Impact Profile (OHIP-14), Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) were also administered. Results: The patients subjected to PBM therapy showed a significant improvement of xerostomia based on the drainage test, and of oral quality of life (p < 0.001). The depression score of the HAD (HAD-D) and the ESS showed improvement, though without reaching statistical significance (p > 0.05). The placebo group showed significant changes in the xerostomia VAS score at 6 weeks (p = 0.009), with no variations in any of the other studied parameters (p > 0.05). The beneficial effects of the diode laser in the PBM group persisted at one year post-treatment. Conclusions: Photobiomodulation with the diode laser is effective in patients with xerostomia and hyposalivation, and thus should be taken into account as a treatment option.
评估光生物调节（PBM）治疗对口干症和唾液分泌减少患者的疗效，并在一年的随访期内评估其生活质量。材料与方法：一项单盲随机对照试验。共纳入60例口干症患者（30例PBM治疗组和30例安慰剂对照组）。使用二极管激光（810 nm，6 J/cm²）进行光生物调节，而对照组接受模拟治疗。每周进行一次治疗，共6周（总计6次治疗）。在基线、治疗3周和6周后以及治疗后一年记录研究参数。使用唾液流量视觉模拟量表（VAS）和口干症量表（XI）评估口干症。还使用医院焦虑抑郁量表（HAD）、口腔健康影响程度量表（OHIP - 14）、匹兹堡睡眠质量指数（PSQI）和爱泼华嗜睡量表（ESS）进行评估。结果：接受PBM治疗的患者在引流试验中显示口干症有显著改善，口腔生活质量也有显著改善（p < 0.001）。HAD量表的抑郁评分（HAD - D）和ESS评分有所改善，但未达到统计学显著性（p > 0.05）。安慰剂组在6周时口干症VAS评分有显著变化（p = 0.009），其他任何研究参数均无变化（p > 0.05）。PBM组中二极管激光的有益效果在治疗后一年持续存在。结论：二极管激光光生物调节对口干症和唾液分泌减少患者有效，因此应作为一种治疗选择加以考虑。
