左心室辅助装置作为晚期心力衰竭缓解的桥梁：当前数据与改进机会
LVAD as a Bridge to Remission from Advanced Heart Failure: Current Data and Opportunities for Improvement.
作者信息
Kyriakopoulos Christos P, Kapelios Chris J, Stauder Elizabeth L, Taleb Iosif, Hamouche Rana, Sideris Konstantinos, Koliopoulou Antigone G, Bonios Michael J, Drakos Stavros G
机构信息
Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health & School of Medicine, Salt Lake City, UT 84132, USA.
Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA.
出版信息
J Clin Med. 2022 Jun 20;11(12):3542. doi: 10.3390/jcm11123542.
Left ventricular assist devices (LVADs) are an established treatment modality for advanced heart failure (HF). It has been shown that through volume and pressure unloading they can lead to significant functional and structural cardiac improvement, allowing LVAD support withdrawal in a subset of patients. In the first part of this review, we discuss the historical background, current evidence on the incidence and assessment of LVAD-mediated cardiac recovery, and out-comes including quality of life after LVAD support withdrawal. In the second part, we discuss current and future opportunities to promote LVAD-mediated reverse remodeling and improve our pathophysiological understanding of HF and recovery for the benefit of the greater HF population.
左心室辅助装置（LVADs）是治疗晚期心力衰竭（HF）的一种既定治疗方式。研究表明，通过容量和压力卸载，它们可显著改善心脏功能和结构，使一部分患者能够撤掉LVAD支持。在本综述的第一部分，我们讨论了历史背景、关于LVAD介导的心脏恢复的发生率和评估的当前证据，以及撤掉LVAD支持后的生活质量等结果。在第二部分，我们讨论当前和未来促进LVAD介导的逆向重构以及增进我们对HF病理生理学和恢复的理解的机会，以造福更多HF患者群体。
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