Houston Methodist Academic Institute, Houston, Texas, US.
Methodist Debakey Cardiovasc J. 2024 Aug 20;20(4):31-41. doi: 10.14797/mdcvj.1400. eCollection 2024.
Myocardial recovery is characterized by a return toward normal structure and function of the heart after an injury. Mechanisms of myocardial recovery include restoration and/or adaptation of myocyte structure and function, mitochondrial activity and number, metabolic homeostasis, electrophysiological stability, extracellular matrix remodeling, and myocardial perfusion. Myocardial regeneration is an element of myocardial recovery that involves the generation of new myocardial tissue, a process which is limited in adult humans but may be therapeutically augmented. Understanding the mechanisms of myocardial recovery and myocardial regeneration will lead to novel therapies for heart failure.
心肌恢复的特征是心脏在损伤后向正常结构和功能的回归。心肌恢复的机制包括肌细胞结构和功能的恢复和/或适应、线粒体活性和数量、代谢稳态、电生理稳定性、细胞外基质重塑和心肌灌注。心肌再生是心肌恢复的一个组成部分，它涉及新心肌组织的产生，这一过程在成年人体内受到限制，但可能通过治疗得到增强。了解心肌恢复和心肌再生的机制将为心力衰竭的治疗带来新的方法。
