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术后子宫内膜癌近距离治疗中治疗源驻留时间的体内验证:一项可行性研究

In Vivo Verification of Treatment Source Dwell Times in Brachytherapy of Postoperative Endometrial Carcinoma: A Feasibility Study.

作者信息

Herreros Antonio, Pérez-Calatayud José, Ballester Facundo, Barrera-Gómez Jose, Abellana Rosa, Melo Joana, Moutinho Luis, Tagliaferri Luca, Rovirosa Ángeles

机构信息

Fonaments Clínics Department, University of Barcelona, 08036 Barcelona, Spain.

Radiation Oncology Department, Hospital Clínic Universitari, 08036 Barcelona, Spain.

出版信息

J Pers Med. 2022 May 31;12(6):911. doi: 10.3390/jpm12060911.

Abstract

(1) Background: In brachytherapy, there are still many manual procedures that can cause adverse events which can be detected with in vivo dosimetry systems. Plastic scintillator dosimeters (PSD) have interesting properties to achieve this objective such as real-time reading, linearity, repeatability, and small size to fit inside brachytherapy catheters. The purpose of this study was to evaluate the performance of a PSD in postoperative endometrial brachytherapy in terms of source dwell time accuracy. (2) Methods: Measurements were carried out in a PMMA phantom to characterise the PSD. Patient measurements in 121 dwell positions were analysed to obtain the differences between planned and measured dwell times. (3) Results: The repeatability test showed a relative standard deviation below 1% for the measured dwell times. The relative standard deviation of the PSD sensitivity with accumulated absorbed dose was lower than 1.2%. The equipment operated linearly in total counts with respect to absorbed dose and also in count rate versus absorbed dose rate. The mean (standard deviation) of the absolute differences between planned and measured dwell times in patient treatments was 0.0 (0.2) seconds. (4) Conclusions: The PSD system is useful as a quality assurance tool for brachytherapy treatments.

摘要

(1) 背景:在近距离放射治疗中,仍有许多手工操作可能导致不良事件,而这些事件可通过体内剂量测定系统检测出来。塑料闪烁体剂量计(PSD)具有实现这一目标的有趣特性,如实时读数、线性、可重复性以及尺寸小以便能放入近距离放射治疗导管内。本研究的目的是从源驻留时间准确性方面评估PSD在术后子宫内膜近距离放射治疗中的性能。(2) 方法:在聚甲基丙烯酸甲酯模体中进行测量以表征PSD。分析了121个驻留位置的患者测量数据,以获得计划驻留时间与测量驻留时间之间的差异。(3) 结果:重复性测试表明,测量的驻留时间相对标准偏差低于1%。PSD灵敏度随累积吸收剂量的相对标准偏差低于1.2%。该设备在总计数相对于吸收剂量以及计数率相对于吸收剂量率方面呈线性运行。患者治疗中计划驻留时间与测量驻留时间之间绝对差异的平均值(标准差)为0.0(0.2)秒。(4) 结论:PSD系统作为近距离放射治疗的质量保证工具很有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c1b/9224704/f6aff681cde7/jpm-12-00911-g001.jpg

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