Ganji Vijay, Sukik Layan, Hoque Bushra, Boutefnouchet Linda, Shi Zumin
Human Nutrition Department, College of Health Sciences, QU Health, Qatar University, Doha P.O. Box 2713, Qatar.
J Pers Med. 2022 Jun 9;12(6):944. doi: 10.3390/jpm12060944.
The association between serum 25-hydroxyvitamin D [25(OH)D] concentration and breast cancer risk in postmenopausal women is not well understood. The aim of this study was to investigate the association between serum 25(OH)D concentration and breast cancer in postmenopausal women in the United States using nationally representative sample surveys. We used the data from seven cycles of National Health and Nutrition Examination Surveys from 2001 to 2014. Participants were non-institutionalized postmenopausal women (n = 8108). In restricted cubic spline analysis, a significant, nonlinear, invert ‘U’ relationship was observed between serum 25(OH)D concentrations and breast cancer in postmenopausal women (p = 0.029). Overall, breast cancer risk was highest (OR = 1.5) between 70 nmol/L and 80 nmol/L of serum 25(OH)D concentration. Then after serum 25(OH)D 80 nmol/L concentration, the breast cancer risk declined. In multivariate-adjusted logistic regression, the risk of having breast cancer was significantly higher in serum 25(OH)D 75−˂100 nmol/L category compared to the 25(OH)D < 30 nmol/L category [OR and 95% CI: 2.4 (1.4−4.0)]. In conclusion, serum vitamin D concentrations ≥ 100 nmol/L are associated with reduced risk of breast cancer in postmenopausal women. Controlled trials are required to verify if serum 25(OH)D ≥ 100 nmol/L offers protection against breast cancer in postmenopausal women.
绝经后女性血清25-羟基维生素D[25(OH)D]浓度与乳腺癌风险之间的关联尚未完全明确。本研究旨在利用具有全国代表性的样本调查，探究美国绝经后女性血清25(OH)D浓度与乳腺癌之间的关联。我们使用了2001年至2014年七个周期的国家健康与营养检查调查数据。参与者为非机构化的绝经后女性（n = 8108）。在受限立方样条分析中，观察到绝经后女性血清25(OH)D浓度与乳腺癌之间存在显著的非线性倒“U”关系（p = 0.029）。总体而言，血清25(OH)D浓度在70 nmol/L至80 nmol/L之间时，乳腺癌风险最高（OR = 1.5）。在血清25(OH)D浓度达到80 nmol/L之后，乳腺癌风险下降。在多变量调整的逻辑回归分析中，与25(OH)D < 30 nmol/L组相比，血清25(OH)D浓度在75−˂100 nmol/L组患乳腺癌的风险显著更高[OR及95%CI：2.4(1.4−4.0)]。总之，血清维生素D浓度≥100 nmol/L与绝经后女性乳腺癌风险降低相关。需要进行对照试验来验证血清25(OH)D≥100 nmol/L是否能为绝经后女性提供预防乳腺癌的保护作用。
