Department of Cardiology, Jinshan Branch of Shanghai Sixth People's Hospital, Shanghai 201500, China.
Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Int J Clin Pract. 2023 Feb 13;2023:1621873. doi: 10.1155/2023/1621873. eCollection 2023.
In the American population, the relationship between the standardized serum 25-hydroxyvitamin D (25(OH)D) concentration and the risk of abdominal aortic calcification (AAC) is unclear. The purpose of our study was to investigate the relationship between serum 25(OH)D concentration and AAC risk. Participants from the National Health and Nutrition Examination Survey (NHANES) between 2013 and 2014 were analyzed cross sectionally. An analysis of the relationship between serum 25(OH)D concentration and incident AAC and severe AAC (SAAC) was based on the restricted cubic spline (RCS) and multivariable logistic regression model. In addition, generalized additive models with smooth functions were used to evaluate the relationship between serum 25(OH)D concentration and the degree of AAC. Finally, a subgroup analysis was conducted. There were a total of 3,040 individuals in our study. The serum 25(OH)D concentration was divided into quartiles (Q1: 9.37-50.5 nmol/L; Q2: 50.6-67.2 nmol/L; Q3: 67.3-85.8 nmol/L; and Q4: 85.9-318.0 nmol/L); the lowest quartile served as the reference group (Q1). After adjusting for known confounding variables, compared with the lowest quartile (Q1) of serum 25(OH)D concentration, the odds ratios with 95% confidence intervals for AAC and SAAC across the quartiles (Q2, Q3, and Q4) were (1.042 (0.812, 1.338), 0.863 (0.668, 1.115), and 1.022 (0.787, 1.327)) and (1.48 (0.87, 2.52), 1.70 (1.01, 2.92), and 2.13 (1.19, 3.86)), respectively. As shown by the RCS plot, the serum 25(OH)D concentration was associated with the risk of AAC/SAAC in a U-shaped pattern ( for nonlinearity <0.05). In addition, the degree of AAC decreased at first and then increased as the serum 25(OH)D concentration increased. In conclusion, a U-shaped relationship existed between serum 25(OH)D concentration and the risk of AAC and SAAC. Consequently, the risk of AAC and SAAC may be mitigated with regular monitoring and vitamin D supplementation.
在美国人群中，标准化血清 25-羟维生素 D（25（OH）D）浓度与腹主动脉钙化（AAC）风险之间的关系尚不清楚。我们的研究目的是探讨血清 25（OH）D 浓度与 AAC 风险之间的关系。对 2013 年至 2014 年期间国家健康和营养检查调查（NHANES）的参与者进行了横断面分析。基于限制立方样条（RCS）和多变量逻辑回归模型分析了血清 25（OH）D 浓度与 AAC 和严重 AAC（SAAC）事件之间的关系。此外，还使用广义加性模型的平滑函数来评估血清 25（OH）D 浓度与 AAC 程度之间的关系。最后进行了亚组分析。我们的研究共有 3040 人。血清 25（OH）D 浓度分为四分位数（Q1：9.37-50.5 nmol/L；Q2：50.6-67.2 nmol/L；Q3：67.3-85.8 nmol/L；Q4：85.9-318.0 nmol/L）；最低四分位数作为参考组（Q1）。在调整了已知的混杂变量后，与血清 25（OH）D 浓度的最低四分位数（Q1）相比，四分位数（Q2、Q3 和 Q4）的 AAC 和 SAAC 的比值比（95%置信区间）分别为（1.042（0.812，1.338），0.863（0.668，1.115）和 1.022（0.787，1.327））和（1.48（0.87，2.52），1.70（1.01，2.92）和 2.13（1.19，3.86））。RCS 图显示，血清 25（OH）D 浓度与 AAC/SAAC 风险呈 U 形关系（非线性<0.05）。此外，随着血清 25（OH）D 浓度的增加，AAC 的程度先降低然后增加。总之，血清 25（OH）D 浓度与 AAC 和 SAAC 风险之间存在 U 形关系。因此，定期监测和维生素 D 补充可能会降低 AAC 和 SAAC 的风险。
