Department of Obstetrics and Gynecology, University of Medicine and Pharmacy "Gr. T. Popa", 700115 Iași, Romania.
Clinical Hospital of Obstetrics and Pharmacy "Elena Doamna", 700398 Iași, Romania.
Medicina (Kaunas). 2022 Jun 8;58(6):776. doi: 10.3390/medicina58060776.
: Kisspeptin, also named metastin, showed important roles in initiating the secretion of gonadotropin-releasing hormone (GnRH) and is an essential factor in the development of polycystic ovaries syndrome (PCOS). Several research studies noticed associations between kisspeptin levels and patients with anovulatory cycles due to PCOS with an increased LH/FSH ratio. The aim of our study was to bring scientific evidence regarding the correlation between high kisspeptin and luteinizing hormone values in subfertile women due to PCOS. A prospective case-control study was conducted in "Elena Doamna" Hospital of Obstetrics and Gynecology between 4 January 2021 and 1 March 2022. All patients agreed to participate in our study, had ages between 18 and 45 years old, and had a body mass index between 18.5 and 30 kg/m. The study group consisted of subfertile patients with PCOS and menstrual disturbances, including amenorrhea or oligomenorrhea. The control group consisted of healthy patients with ovulatory cycles and no other reproductive or endocrinology pathologies. During the follicular phase of their menstrual cycle, patients had blood samples taken with the dosage of kisspeptin, LH, FSH, estradiol, insulin, glycemic levels, testosterone, and prolactin. Pelvic ultrasounds and clinical examinations were performed as well. : Significant differences were observed in kisspeptin, LH, FSH, and estradiol levels between patients with PCOS and the control group. After the univariate analysis, PCOS was significantly associated with increased kisspeptin, increased LH, and decreased FSH. There was no significant association between PCOS, estradiol, prolactin, and insulin. : kisspeptin serum values are higher in subfertile PCOS patients, supporting the hypothesis that an over-stimulation of the KISS1 system might cause the hyper-stimulation of the HPG-axis.
: 促性腺激素释放激素（GnRH）的分泌启动中， kisspeptin（也称为 metastin）发挥着重要作用，是多囊卵巢综合征（PCOS）发展的重要因素。一些研究注意到，由于 PCOS 导致的无排卵周期患者的 kisspeptin 水平与 LH/FSH 比值升高之间存在关联。我们的研究目的是提供关于 PCOS 导致的不育妇女中高 kisspeptin 与黄体生成素值之间相关性的科学证据。一项前瞻性病例对照研究于 2021 年 1 月 4 日至 2022 年 3 月 1 日在“Elena Doamna”妇产科医院进行。所有患者均同意参与我们的研究，年龄在 18 至 45 岁之间，体重指数在 18.5 至 30kg/m 之间。研究组由患有 PCOS 和月经紊乱的不育患者组成，包括闭经或月经稀发。对照组由月经周期有排卵且无其他生殖或内分泌病理学的健康患者组成。在月经周期的卵泡期，患者采集 kisspeptin、LH、FSH、雌二醇、胰岛素、血糖水平、睾酮和催乳素的血样。还进行了盆腔超声和临床检查。: PCOS 患者与对照组之间的 kisspeptin、LH、FSH 和雌二醇水平存在显著差异。单因素分析后，PCOS 与 kisspeptin 升高、LH 升高和 FSH 降低显著相关。PCOS 与雌二醇、催乳素和胰岛素无显著相关性。: 不育 PCOS 患者血清 kisspeptin 值较高，支持了 KISS1 系统过度刺激可能导致 HPG 轴过度刺激的假说。
