Hossain Khandkar Shaharina, Amarasena Sathya, Mayengbam Shyamchand
Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL A1C 5S7, Canada.
Microorganisms. 2022 Jun 7;10(6):1168. doi: 10.3390/microorganisms10061168.
B vitamins act as coenzymes in a myriad of cellular reactions. These include energy production, methyl donor generation, neurotransmitter synthesis, and immune functions. Due to the ubiquitous roles of these vitamins, their deficiencies significantly affect the host's metabolism. Recently, novel roles of B vitamins in the homeostasis of gut microbial ecology and intestinal health continue to be unravelled. This review focuses on the functional roles and biosynthesis of B vitamins and how these vitamins influence the growth and proliferation of the gut microbiota. We have identified the gut bacteria that can produce vitamins, and their biosynthetic mechanisms are presented. The effects of B vitamin deficiencies on intestinal morphology, inflammation, and its effects on intestinal disorders are also discussed.
B族维生素在无数细胞反应中作为辅酶发挥作用。这些反应包括能量产生、甲基供体生成、神经递质合成和免疫功能。由于这些维生素具有广泛的作用，它们的缺乏会显著影响宿主的新陈代谢。最近，B族维生素在肠道微生物生态稳态和肠道健康中的新作用不断被揭示。本综述重点关注B族维生素的功能作用和生物合成，以及这些维生素如何影响肠道微生物群的生长和增殖。我们已经确定了能够产生维生素的肠道细菌，并介绍了它们的生物合成机制。还讨论了B族维生素缺乏对肠道形态、炎症的影响及其对肠道疾病的作用。
