Voland Lise, Le Roy Tiphaine, Debédat Jean, Clément Karine
Inserm, Sorbonne University, Nutrition and obesities: systemic approaches (NutriOmics), Paris, France.
Public hospital of Paris, Nutrition department, Pitié-Salpêtrière Hospital, Paris, France.
Obes Rev. 2022 Feb;23(2):e13377. doi: 10.1111/obr.13377. Epub 2021 Nov 12.
There are numerous factors involved in obesity progression and maintenance including systemic low-grade inflammation, adipose tissue dysfunction, or gut microbiota dysbiosis. Recently, a growing interest has arisen for vitamins' role in obesity and related disorders, both at the host and gut bacterial level. Indeed, vitamins are provided mostly by food, but some, from the B and K groups in particular, can be synthesized by the gut bacterial ecosystem and absorbed in the colon. Knowing that vitamin deficiency can alter many important cellular functions and lead to serious health issues, it is important to carefully monitor the vitamin status of patients with obesity and potentially already existing comorbidities as well as to examine the dysbiotic gut microbiota and thus potentially altered bacterial metabolism of vitamins. In this review, we examined both murine and human studies, to assess the prevalence of sub-optimal levels of several vitamins in obesity and metabolic alterations. This review also examines the relationship between vitamins and the gut microbiota in terms of vitamin production and the modulation of the gut bacterial ecosystem in conditions of vitamin shortage or supplementation. Furthermore, some strategies to improve vitamin status of patients with severe obesity are proposed within this review.
肥胖的进展和维持涉及众多因素，包括全身性低度炎症、脂肪组织功能障碍或肠道微生物群失调。最近，维生素在肥胖及相关疾病中的作用在宿主和肠道细菌层面都引起了越来越多的关注。事实上，维生素大多由食物提供，但某些维生素，特别是B族和K族中的一些维生素，可由肠道细菌生态系统合成并在结肠中吸收。鉴于维生素缺乏会改变许多重要的细胞功能并导致严重的健康问题，仔细监测肥胖患者以及可能已存在合并症患者的维生素状态，并检查失调的肠道微生物群以及由此可能改变的维生素细菌代谢，是很重要的。在本综述中，我们研究了小鼠和人类研究，以评估肥胖中几种维生素水平未达最佳状态的患病率以及代谢改变情况。本综述还从维生素产生以及在维生素缺乏或补充情况下肠道细菌生态系统的调节方面，研究了维生素与肠道微生物群之间的关系。此外，本综述还提出了一些改善重度肥胖患者维生素状态的策略。
