Departament de Química Orgànica, Facultad de Química, Universitat de València, C/Dr. Moliner 50, 46100 Burjassot, Spain.
Molecules. 2022 Jun 11;27(12):3763. doi: 10.3390/molecules27123763.
A convenient procedure of synthesis of -carbamoyl-protected propargylic amines substituted with a cyclopropyl group from α-amido sulfones and cyclopropylacetylene is described. The reaction is catalyzed by a chiral BINOL-type zinc complex and provides the corresponding products in good yields and enantioselectivities.
描述了一种方便的合成方法，通过α-酰胺砜和环丙基乙炔合成 - 氨甲酰基保护的丙炔基胺，其中取代有环丙基。该反应由手性 BINOL 型锌配合物催化，以良好的产率和对映选择性得到相应产物。
