Kashapov Ruslan R, Razuvayeva Yuliya S, Lukashenko Svetlana S, Amerhanova Syumbelya K, Lyubina Anna P, Voloshina Alexandra D, Syakaev Victor V, Salnikov Vadim V, Zakharova Lucia Y
Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, 8 Arbuzov Street, 420088 Kazan, Russia.
Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, 2/31 Lobachevsky Street, 420111 Kazan, Russia.
Nanomaterials (Basel). 2022 Jun 9;12(12):1986. doi: 10.3390/nano12121986.
The combined method of treating malignant neoplasms using photodynamic therapy and chemotherapy is undoubtedly a promising and highly effective treatment method. The development and establishment of photodynamic cancer therapy is closely related to the creation of sensitizers based on porphyrins. The present study is devoted to the investigation of the spectroscopic, aggregation, and solubilization properties of the supramolecular system based on 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin (TSPP) and lanthanum-containing surfactant (LaSurf) in an aqueous medium. The latter is a complex of lanthanum nitrate and two cationic amphiphilic molecules of 4-aza-1-hexadecylazoniabicyclo[2.2.2]octane bromide. The mixed TSPP-LaSurf complexes can spontaneously assemble into various nanostructures capable of binding the anticancer drug cisplatin. Morphological behavior, stability, and ability to drug binding of nanostructures can be tailored by varying the molar ratio and the concentration of components. The guest binding is shown to be additional factor controlling structural rearrangements and properties of the supramolecular TSPP-LaSurf complexes.
使用光动力疗法和化疗联合治疗恶性肿瘤的方法无疑是一种有前景且高效的治疗方法。光动力癌症治疗的发展与基于卟啉的敏化剂的创制密切相关。本研究致力于研究基于5,10,15,20-四（4-磺酸苯基）卟啉（TSPP）和含镧表面活性剂（LaSurf）的超分子体系在水介质中的光谱、聚集和增溶性质。后者是硝酸镧与两个4-氮杂-1-十六烷基氮杂双环[2.2.2]辛烷溴化物阳离子两亲分子的络合物。混合的TSPP-LaSurf络合物能够自发组装成各种能够结合抗癌药物顺铂的纳米结构。通过改变组分的摩尔比和浓度，可以调整纳米结构的形态行为、稳定性和药物结合能力。客体结合被证明是控制超分子TSPP-LaSurf络合物结构重排和性质的另一个因素。
