Kakarla Akesh Babu, Kong Ing
School of Computing, Engineering and Mathematical Sciences, La Trobe University, Bendigo, VIC 3552, Australia.
Nanomaterials (Basel). 2022 Jun 15;12(12):2069. doi: 10.3390/nano12122069.
Boron nitride nanotubes (BNNTs) are an exciting class of nanomaterials due to their unique chemical and physical characteristics. In recent decades, BNNTs have gained huge attention in research and development for various applications, including as nano-fillers for composites, semiconductor devices, hydrogen storage, and as an emerging material in biomedical and tissue engineering applications. However, the toxicity of BNNTs is not clear, and the biocompatibility is not proven yet. In this review, the role of BNNTs in biocompatibility studies is assessed in terms of their characteristics: cell viability, proliferation, therapeutic outcomes, and genotoxicity, which are vital elements for their prospective use in biomedical applications. A systematic review was conducted utilising the databases Scopus and Web of Science (WOS) (2008-2022). Additional findings were discovered manually by snowballing the reference lists of appropriate reviews. Only English-language articles were included. Finally, the significant analysis and discussion of the chosen articles are presented.
氮化硼纳米管（BNNTs）因其独特的化学和物理特性而成为一类令人瞩目的纳米材料。近几十年来，BNNTs在各种应用的研发中受到了广泛关注，包括作为复合材料的纳米填料、半导体器件、储氢材料，以及生物医学和组织工程应用中的新兴材料。然而，BNNTs的毒性尚不清楚，其生物相容性也尚未得到证实。在本综述中，从细胞活力、增殖、治疗效果和基因毒性等特性方面评估了BNNTs在生物相容性研究中的作用，这些特性是其在生物医学应用中潜在用途的关键要素。利用Scopus和科学网（WOS）数据库（2008 - 2022年）进行了系统综述。通过对相关综述的参考文献列表进行滚雪球式检索，手动发现了其他研究结果。仅纳入英文文章。最后，对所选文章进行了重要分析和讨论。
