Giles T D, Holder J T
J Clin Pharmacol. 1978 Aug-Sep;18(8-9):407-13. doi: 10.1002/j.1552-4604.1978.tb02457.x.
The effects of 10 mg sublingual pentrinitrol and placebo on the exercise tolerance of 20 patients with angina pectoris were compared. The ten patients who received pentrinitrol had increases in exercise times and metabolic oxygen equivalents (METs) 15 and 60 minutes after administration, whereas no change occurred in ten comparable patients receiving placebo. Pentrinitrol produced lower preexercise systolic blood pressures and systolic blood pressures at point of angina. An increase in heart rate offset the effect of the reduced systolic blood pressure on double product (systolic blood pressure times heart rate). Sublingual pentrinitrol is an effective antianginal drug for at least 60 minutes.
比较了10毫克舌下含服戊四硝酯和安慰剂对20例心绞痛患者运动耐量的影响。接受戊四硝酯的10例患者在给药后15分钟和60分钟时运动时间和代谢当量（METs）增加，而接受安慰剂的10例对照患者则无变化。戊四硝酯使运动前收缩压和心绞痛发作时的收缩压降低。心率增加抵消了收缩压降低对双乘积（收缩压乘以心率）的影响。舌下含服戊四硝酯至少60分钟内是一种有效的抗心绞痛药物。
